Featured Research

from universities, journals, and other organizations

EMT contributes to vision loss due to bone marrow transplantation

Date:
November 25, 2009
Source:
American Journal of Pathology
Summary:
Researchers have discovered that epithelial-mesenchymal transition (EMT) plays a role in damage in the eye after bone marrow transplantation.

Researchers from the Keio University, School of Medicine, Tokyo, Japan have discovered that epithelial-mesenchymal transition (EMT) plays a role in damage in the eye after bone marrow transplantation. These results are presented in the December 2009 issue of The American Journal of Pathology.

Related Articles


After bone marrow transplantation, transplanted immune cells can recognize the graft recipient as foreign (similar to how the immune system recognizes bacteria as foreign), resulting in an attack on host tissues. When this attack occurs in the eye, it may lead to vision loss and excessive fibrosis.

EMT, which is characterized by a change in cells from adherent to mobile, has been implicated in fibrotic diseases. Ogawa et al therefore explored the potential role of EMT in eye disease following bone marrow transplantation. They observed several features of EMT in eyes after bone marrow transplantation including down-regulation of adhesion molecules and up-regulation of EMT markers in epithelial cells. These results indicate that EMT may be at least partially responsible for fibrotic eye damage in patients following bone marrow transplantation.

Ogawa et al suggest that "a full understanding of the contribution of different extracellular triggers in … fibrosis [in the eye] will elucidate the mechanism of the dynamic process of EMT [in transplanted cell attack on the new host] and improve the quality of life of patients [after bone marrow transplantation]."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ogawa et al. Epithelial Mesenchymal Transition in Human Ocular Chronic Graft-Versus-Host Disease. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.090318

Cite This Page:

American Journal of Pathology. "EMT contributes to vision loss due to bone marrow transplantation." ScienceDaily. ScienceDaily, 25 November 2009. <www.sciencedaily.com/releases/2009/11/091125145823.htm>.
American Journal of Pathology. (2009, November 25). EMT contributes to vision loss due to bone marrow transplantation. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/11/091125145823.htm
American Journal of Pathology. "EMT contributes to vision loss due to bone marrow transplantation." ScienceDaily. www.sciencedaily.com/releases/2009/11/091125145823.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins