Featured Research

from universities, journals, and other organizations

New light shed on epilepsy

Date:
December 1, 2009
Source:
Newcastle University
Summary:
Neuroscientists move a step closer to finding new treatments for epilepsy.

Pioneering research using human brain tissue removed from people suffering from epilepsy has opened the door to new treatments for the disease.

Related Articles


Scientists at Newcastle University have for the first time been able to record spontaneous epileptic activity in brain tissue that has been removed from patients undergoing neurosurgery.

Led by Newcastle University's Dr Mark Cunningham, the research has revealed that a particular type of brain wave pattern associated with epilepsy is caused by electrical connections between nerve cells in the brain -- rather than chemical ones. This means the traditional drugs are useless to them.

Published in the Proceedings of the National Academy of Sciences (PNAS), Dr Cunningham said the findings marked a huge step forward in our understanding of a disease which affects an estimated 45 million people worldwide.

"Until now we have only been able to mimic epilepsy using experimental animal models but this can never give you a true picture of what is actually going on inside the human brain in epilepsy," explained Dr Cunningham who is based in Newcastle University's Institute of Neuroscience.

"Our findings help us to understand what is going wrong and are an important step towards finding new epilepsy treatments in the future."

The study

The first line of treatment for patients with epilepsy uses anti-epileptic drugs to control seizures.

However, in almost 30 per cent of patients the drugs don't work. In this case, one course of action available to them is a neurosurgical procedure in which the brain tissue responsible for the epilepsy is removed from the patient.

Working in collaboration with the Epilepsy Surgery Group at Newcastle General Hospital and IBM Watson Research Centre in New York, the team -- with permission from the patients -- have taken this epileptic tissue into the lab and 'fooled' it into thinking it is still part of the living brain.

They have then been able to record electrical signals from individual neurons and also networks of neurons.

Comparing this with normal brain tissue activity they managed to record an underlying 'noise' -- a particular type of brain wave, or oscillation, which occurs in the intact epileptic human brain and which scientists believe is a precursor to an epileptic seizure.

Using a combination of experimental techniques, the team have shown that rather than being controlled by chemical signals which most conventional anti-epileptic drugs target, this oscillation relies on direct electrical connections.

"This may explain why the traditional drugs that target chemical connections don't work for patients with this kind of epilepsy," explains Dr Cunningham, who conducted the research with his colleague Professor Miles Whittington.

"These findings have massively increased our understanding of epilepsy and offer real hope in terms of finding new ways of tackling the disease.

"The next step is to understand what it is that triggers the transition between the underlying epileptic state of the brain cells and the fast oscillations that are responsible for causing a seizure."


Story Source:

The above story is based on materials provided by Newcastle University. Note: Materials may be edited for content and length.


Cite This Page:

Newcastle University. "New light shed on epilepsy." ScienceDaily. ScienceDaily, 1 December 2009. <www.sciencedaily.com/releases/2009/11/091130151323.htm>.
Newcastle University. (2009, December 1). New light shed on epilepsy. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/11/091130151323.htm
Newcastle University. "New light shed on epilepsy." ScienceDaily. www.sciencedaily.com/releases/2009/11/091130151323.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins