Featured Research

from universities, journals, and other organizations

Hope for men with nonobstructive infertility

Date:
December 4, 2009
Source:
BioMed Central
Summary:
It has been thought that men with nonobstructive azoospermia (NOA), a lack of sperm in the semen not caused by an obstruction within the reproductive system, are poor candidates for in vitro fertilization. Now, researchers have shown that sperm from men with NOA and obstructive azoospermia are equally capable of producing embryos.

It has been thought that men with non-obstructive azoospermia (NOA), a lack of sperm in the semen not caused by an obstruction within the reproductive system, are poor candidates for IVF. Now, researchers writing in the open access journal Reproductive Biology and Endocrinology have shown that sperm from men with NOA and obstructive azoospermia (OA) are equally capable of producing embryos.

Nina Desai led a team of researchers from the Cleveland Clinic Foundation who carried out an in-depth analysis of intracytoplasmic sperm injection (ICSI) using frozen sperm taken from the testes of 44 men with OA and 17 men with NOA. They found that, although fertilization rates were slightly improved in the OA group, there were no significant differences in implantation rates or clinical pregnancy rates.

According to Desai, "The high implantation rate per embryo transferred and the resultant live births attest to the quality of embryos being produced with both types of surgically retrieved sperm."

In addition to evaluating the feasibility of NOA sperm, the researchers were also able to study paternal effect on genomic activation. One of the earliest morphologic indicators of embryonic genome activation is increased cell-to-cell adherence at the 8-cell stage, leading to compaction.

Desai said, "Interestingly, we found that embryonic compaction was similar in all three groups. These results suggest that zygotic activation is independent of sperm origin and type of azoospermia."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nina Desai, Faten AbdelHafez, Edmund Sabanegh and James Goldfarb. Paternal effect on genomic activation, clinical pregnancy and live birth rate after ICSI with cryopreserved epididymal versus testicular spermatozoa. Reproductive Biology and Endocrinology, 2009; (in press) [link]

Cite This Page:

BioMed Central. "Hope for men with nonobstructive infertility." ScienceDaily. ScienceDaily, 4 December 2009. <www.sciencedaily.com/releases/2009/12/091202205623.htm>.
BioMed Central. (2009, December 4). Hope for men with nonobstructive infertility. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/12/091202205623.htm
BioMed Central. "Hope for men with nonobstructive infertility." ScienceDaily. www.sciencedaily.com/releases/2009/12/091202205623.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins