Featured Research

from universities, journals, and other organizations

Hope for men with nonobstructive infertility

Date:
December 4, 2009
Source:
BioMed Central
Summary:
It has been thought that men with nonobstructive azoospermia (NOA), a lack of sperm in the semen not caused by an obstruction within the reproductive system, are poor candidates for in vitro fertilization. Now, researchers have shown that sperm from men with NOA and obstructive azoospermia are equally capable of producing embryos.

It has been thought that men with non-obstructive azoospermia (NOA), a lack of sperm in the semen not caused by an obstruction within the reproductive system, are poor candidates for IVF. Now, researchers writing in the open access journal Reproductive Biology and Endocrinology have shown that sperm from men with NOA and obstructive azoospermia (OA) are equally capable of producing embryos.

Related Articles


Nina Desai led a team of researchers from the Cleveland Clinic Foundation who carried out an in-depth analysis of intracytoplasmic sperm injection (ICSI) using frozen sperm taken from the testes of 44 men with OA and 17 men with NOA. They found that, although fertilization rates were slightly improved in the OA group, there were no significant differences in implantation rates or clinical pregnancy rates.

According to Desai, "The high implantation rate per embryo transferred and the resultant live births attest to the quality of embryos being produced with both types of surgically retrieved sperm."

In addition to evaluating the feasibility of NOA sperm, the researchers were also able to study paternal effect on genomic activation. One of the earliest morphologic indicators of embryonic genome activation is increased cell-to-cell adherence at the 8-cell stage, leading to compaction.

Desai said, "Interestingly, we found that embryonic compaction was similar in all three groups. These results suggest that zygotic activation is independent of sperm origin and type of azoospermia."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nina Desai, Faten AbdelHafez, Edmund Sabanegh and James Goldfarb. Paternal effect on genomic activation, clinical pregnancy and live birth rate after ICSI with cryopreserved epididymal versus testicular spermatozoa. Reproductive Biology and Endocrinology, 2009; (in press) [link]

Cite This Page:

BioMed Central. "Hope for men with nonobstructive infertility." ScienceDaily. ScienceDaily, 4 December 2009. <www.sciencedaily.com/releases/2009/12/091202205623.htm>.
BioMed Central. (2009, December 4). Hope for men with nonobstructive infertility. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2009/12/091202205623.htm
BioMed Central. "Hope for men with nonobstructive infertility." ScienceDaily. www.sciencedaily.com/releases/2009/12/091202205623.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins