Featured Research

from universities, journals, and other organizations

Light shed on mechanism of action of 'date rape drug'

Date:
December 7, 2009
Source:
Case Western Reserve University
Summary:
Scientists have discovered two new metabolic pathways by which products of lipid peroxidation and some drugs of abuse, known as 4-hydroxyacids, are metabolized. The pathways were identified by a combination of metabolomics and mass isotopomer analysis. The findings shed new light on the mechanism of action of the drug of abuse gamma-hydroxybutyrate, also known as "the date rape drug."

Case Western Reserve University researchers, from the School of Medicine's Department of Nutrition, discovered two new metabolic pathways by which products of lipid peroxidation and some drugs of abuse, known as 4-hydroxyacids, are metabolized. The pathways were identified by a combination of metabolomics and mass isotopomer analysis. The findings shed new light on the mechanism of action of the drug of abuse gamma-hydroxybutyrate, also known as "the date rape drug."

"Our finding will lead to studies that will increase the understanding of metabolic disturbances that occur during oxidative stress. The latter is part of the pathology of heart attacks, stroke, diabetes and inflammation," says Guo-Fang Zhang, Ph.D., Research Associate in the Department of Nutrition at Case Western Reserve School of Medicine. "We hope that the upcoming studies will lead to the design of new treatments that minimize the effects of oxidative stress."

"A combined effort of Case Western Reserve University and the Mt. Sinai Health Care Foundation since 1990 has lead to the building of this department's research program and the conception of this groundbreaking finding," says Henri Brunengraber, M.D., Ph.D., Senior Author, Professor, and Chair of the Department of Nutrition. "We plan to expand this project in close collaboration with Gregory P. Tochtrop, Ph.D., Assistant Professor in the Department of Chemistry. Dr. Tochtrop and his group have synthesized a number of carbon 13-labeled compounds which allowed the unraveling of the steps of the new pathways we discovered."

Collaborators of this study also included the Case Western Reserve University Mouse Metabolic Phenotyping Center, run by Dr. Brunengraber and two other faculty from the Department of Nutrition, Dr. Colleen Croniger and Dr. Michelle Puchowicz.

This work was supported by a RoadMap grant from the National Institutes of Health, a grant from the National Institute of Environment Health Sciences, as well as by a grant from the Cleveland Mt. Sinai Health Care Foundation. The RoadMap grant funded the development of metabolomics at Case Western Reserve, as well as the acquisition of a top-of-the-line mass spectrometer. This instrument allowed this and multiple other studies to be conducted. The RoadMap initiative allowed a quantum jump in the development of metabolic research at the School of Medicine.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Cite This Page:

Case Western Reserve University. "Light shed on mechanism of action of 'date rape drug'." ScienceDaily. ScienceDaily, 7 December 2009. <www.sciencedaily.com/releases/2009/12/091204172757.htm>.
Case Western Reserve University. (2009, December 7). Light shed on mechanism of action of 'date rape drug'. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2009/12/091204172757.htm
Case Western Reserve University. "Light shed on mechanism of action of 'date rape drug'." ScienceDaily. www.sciencedaily.com/releases/2009/12/091204172757.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins