Featured Research

from universities, journals, and other organizations

Supportive materials to help regenerate heart tissue

Date:
December 10, 2009
Source:
University of California - San Diego
Summary:
Bioengineers are developing new regenerative therapies for heart disease. The work could influence the way in which regenerative therapies for cardiovascular and other diseases are treated in the future.

Bioengineers from University of California, San Diego are developing new regenerative therapies for heart disease that could influence the way in which regenerative therapies for cardiovascular and other diseases are treated in the future.

Related Articles


New results from UC San Diego on using adult stem cells to regenerate heart tissue in environments that mimic a human post-heart-attack heart were presented in San Diego at the 2009 annual meeting of the American Society for Cell Biology (ASCB). The work is from the laboratory of Adam Engler from the Department of Bioengineering at the UC San Diego Jacobs School of Engineering.

Every year in the United States, approximately 900,000 people die from heart disease. The prevalence of heart disease has prompted researchers to develop new regenerative therapies to treat the condition, including the injection of adult stem cells into the scarred heart muscle that results from a heart attack. This treatment, called cellular cardiomyoplasty, relies on injected stem cells receiving appropriate cues from their surrounding tissue to cause them to become cardiac muscle.

However, when stem cells are injected into stiff, scarred, post-heart attack muscle (rather than healthy tissue), these stem cells do not readily become cardiac muscle. In fact, only marginal improvement in overall cardiac function has been detected, and this improvement may not actually be from tissue regeneration. Instead, the improvements may be from the fact that the treatment "pokes holes" into the scar tissue and injects soft cells, making it slightly softer and thus more functional. Even more striking, the injected stem cells do not form new cardiac muscle. Instead, the stem cells form small calcified lesions. The injected stem cells are directed by the stiff scar tissue to mature into bone-like cells rather than new heart cells.

Given these problems associated with direct stem cell injection, the UC San Diego bioengineers are proposing to use cells placed in a supportive material that changes stiffness with time by exhibiting time-dependent crosslinking.

"Our evidence suggests that tissue-specific stiffness arises from key developmental changes, which implies that cells should be cultured in the appropriate physical conditions that mimic embryonic tissue progression, from soft, pre-cardiac tissue at early embryonic age to a mature, less compliant tissue at the conclusion of development," said Jennifer Young, a Ph.D. candidate in bioengineering at UC San Diego and the first author on the peer-reviewed presentation at ASCB 2009. By tuning this material to mimic in situ time-dependent stiffness changes, the UC San Diego bioengineers have found that cells placed in this material indicate improved cardiac differentiation.

"Results from this study may not only have a profound impact on cardiovascular engineering, but may influence the way in which many regenerative therapies are conducted. In this instance we have studied the developing tissue as a model, and from it generated a set of design criteria to mimic in our new material," said bioengineering professor Adam Engler from the UC San Diego Jacobs School of Engineering.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University of California - San Diego. "Supportive materials to help regenerate heart tissue." ScienceDaily. ScienceDaily, 10 December 2009. <www.sciencedaily.com/releases/2009/12/091208162659.htm>.
University of California - San Diego. (2009, December 10). Supportive materials to help regenerate heart tissue. ScienceDaily. Retrieved March 26, 2015 from www.sciencedaily.com/releases/2009/12/091208162659.htm
University of California - San Diego. "Supportive materials to help regenerate heart tissue." ScienceDaily. www.sciencedaily.com/releases/2009/12/091208162659.htm (accessed March 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins