Featured Research

from universities, journals, and other organizations

Disease-free, overall survival inferior for black women with HR-positive breast cancer

Date:
December 11, 2009
Source:
American Association for Cancer Research
Summary:
Black women with hormone receptor (HR)-positive breast cancer had worse disease-free and overall survival, according to data presented at the CTRC-AACR Annual San Antonio Breast Cancer Symposium, held Dec. 9-13, 2009.

Black women with hormone receptor (HR)-positive breast cancer had worse disease-free and overall survival, according to data presented at the CTRC-AACR Annual San Antonio Breast Cancer Symposium, held Dec. 9-13, 2009.

"Black women had a higher risk for disease recurrence and inferior survival compared with women of other races," said Joseph A. Sparano, M.D., professor of medicine and women's health at Albert Einstein Medical College of Medicine and associate chairman of the Department of Oncology at Montefiore Medical Center in Bronx, N.Y.

"The worse outcome was seen only in those with HR-positive, HER-2-negative breast cancer, which is the most common type of breast cancer" he added.

Previous research has shown that black women have worse outcomes in operable breast cancer, likely explained by their higher incidence of more advanced-stage disease, more aggressive triple-negative disease, disparities in medical care, and comorbidities.

"When we controlled for these other factors to the extent possible, black race was still associated with a worse outcome, but only in HR-positive disease -- this was a new and surprising finding," said Sparano.

The researchers evaluated survival outcomes in 4,817 women (405 were black) with stage 1 to 3 axillary lymph node-positive or high-risk node-negative breast cancer who had undergone surgery. The women were part of the Eastern Cooperative Oncology Group and Breast Cancer Intergroup trial E1199; they received doxorubicin and taxane-containing chemotherapy plus standard hormonal therapy.

"We found that black patients exhibited similar adherence to the chemotherapy and hormonal therapy, and they didn't do worse if they had other breast cancer subtypes. This indicates that black women with HR-positive breast cancer are more prone to have disease recurrence despite state of the art medical care," said Sparano.

The researchers are planning additional studies to evaluate whether these findings can be attributed to differences in black women's ability to metabolize hormonal therapies.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Disease-free, overall survival inferior for black women with HR-positive breast cancer." ScienceDaily. ScienceDaily, 11 December 2009. <www.sciencedaily.com/releases/2009/12/091211131511.htm>.
American Association for Cancer Research. (2009, December 11). Disease-free, overall survival inferior for black women with HR-positive breast cancer. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2009/12/091211131511.htm
American Association for Cancer Research. "Disease-free, overall survival inferior for black women with HR-positive breast cancer." ScienceDaily. www.sciencedaily.com/releases/2009/12/091211131511.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins