Featured Research

from universities, journals, and other organizations

Nanoprobes hit targets in tumors, could lessen chemo side effects

Date:
December 15, 2009
Source:
Purdue University
Summary:
Tiny nanoprobes have shown to be effective in delivering cancer drugs more directly to tumor cells -- mitigating the damage to nearby healthy cells -- and new research has shown that the nanoprobes are getting the drugs to right cellular compartments.

Tiny nanoprobes have shown to be effective in delivering cancer drugs more directly to tumor cells -- mitigating the damage to nearby healthy cells -- and Purdue University research has shown that the nanoprobes are getting the drugs to right cellular compartments.

Related Articles


Professor Joseph Irudayaraj and graduate student Jiji Chen, both in the Department of Agricultural and Biological Engineering, have found that the nanoprobes, or nanorods, when coated with the breast cancer drug Herceptin, are reaching the endosomes of cells, mimicking the delivery of the drug on its own. Endosomes perform a sorting function to deliver drugs and other substances to the appropriate locations.

"We have demonstrated the ability to track these nanoparticles in different cellular compartments of live cells and show where they collect quantitatively," said Irudayaraj, whose results were published early online in the journal ACS Nano. "Our methods will allow us to calculate the quantities of a drug needed to treat a cancer cell because now we know how these nanoparticles are being distributed to different parts of the cell."

The nanoprobes, which are about 1,000 times smaller than the diameter of a human hair, are made from gold and magnetic particles. An MRI machine can track the magnetic portions of the nanoprobes while a more sensitive microscopy process can detect the gold.

The nanoprobes were inserted into live human tumor cells during laboratory testing. Using fluorescent markers to differentiate organelles, or sub-units of cells, Irudayaraj's group was able to determine the number of nanoprobes accumulating in the endosomes, lysosomes and membranes of those cells.

Cancer treatments often use high drug concentrations that damage healthy cells near a tumor. While Herceptin is attracted to and attaches to the proteins on the surface of breast cancer cells, healthy surrounding cells absorb some of the chemotherapy drugs through normal fluidic intake.

Irudayaraj said targeting only tumor cells with nanoprobes would require less drugs and mitigate the side effects of cancer chemotherapy drugs.

"Each nanoparticle acts like a deliverer of a mail package, or dose, of the drug directly to the appropriate location," Irudayaraj said.

In Irudayaraj's laboratory tests, endosomes received a major portion of the nanorods containing Herceptin. Lysosomes, which act like garbage collection units in cells and hinder a drug's effectiveness, received a lower concentration of nanorods.

Irudayaraj said those percentages are similar to how cells distribute drugs through traditional treatments.

Irudayaraj will next try to attach multiple drugs to a nanoparticle and track their distribution within cells. He also wants to determine the timing of a drug's release from the nanoprobes after attaching to the tumor cells.

The research was funded through a Trask Grant and the Purdue Research Foundation.


Story Source:

The above story is based on materials provided by Purdue University. The original article was written by Brian Wallheimer. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jiji Chen and Joseph Irudayaraj. Quantitative Investigation of Compartmentalized Dynamics of ErbB2 Targeting Gold Nanorods in Live Cells by Single Molecule Spectroscopy. ACS Nano, 2009; 091105102806013 DOI: 10.1021/nn900743v

Cite This Page:

Purdue University. "Nanoprobes hit targets in tumors, could lessen chemo side effects." ScienceDaily. ScienceDaily, 15 December 2009. <www.sciencedaily.com/releases/2009/12/091214152020.htm>.
Purdue University. (2009, December 15). Nanoprobes hit targets in tumors, could lessen chemo side effects. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/12/091214152020.htm
Purdue University. "Nanoprobes hit targets in tumors, could lessen chemo side effects." ScienceDaily. www.sciencedaily.com/releases/2009/12/091214152020.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins