Featured Research

from universities, journals, and other organizations

Childhood metabolic measurements may predict diabetes development years later

Date:
January 5, 2010
Source:
JAMA and Archives Journals
Summary:
A child's blood pressure, body mass index, blood glucose level and other laboratory tests and simple office measures may predict the risk of developing type 2 diabetes nine and 26 years later, according to a new study.

A child's blood pressure, body mass index, blood glucose level and other laboratory tests and simple office measures may predict the risk of developing type 2 diabetes nine and 26 years later, according to a report in the January issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

Related Articles


"In the past 25 years, the prevalences of obesity and type 2 diabetes mellitus have increased concomitantly, and the age at onset of type 2 diabetes mellitus has dropped precipitously, especially in black females," the authors write as background information in the article. Models to identify children at high and low risk of type 2 diabetes could provide diagnostic and therapeutic insights and help clinicians target prevention efforts.

John A. Morrison, Ph.D., of Cincinnati Children's Hospital Medical Center, and colleagues analyzed data from two studies. The National Growth and Health Study followed 1,067 black and white girls enrolled at ages 9 and 10 for nine years, and the Princeton Follow-up Study tracked 822 black and white schoolchildren for 22 to 30 years beginning in 1973 to 1976.

In the Princeton Follow-up Study, individuals were more likely to have diabetes at age 39 years if they had high systolic (top number) blood pressure, a high body mass index, glucose levels of at least 100 milligrams per deciliter, low high-density lipoprotein (HDL, or "good" cholesterol) levels and high triglyceride levels in childhood. "When body mass index, systolic blood pressure and diastolic [bottom number] blood pressure were all lower than the 75th percentile and there was no parental diabetes mellitus, the likelihood of children developing type 2 diabetes mellitus 22 to 30 years later was only 1 percent," the authors write.

In the National Growth and Health Study, childhood high systolic blood pressure, insulin concentration and having a parent with diabetes increased the risk of having diabetes at age 19. "If childhood body mass index, systolic blood pressure and diastolic blood pressure were all lower than the 75th percentile, the likelihood of type 2 diabetes mellitus at age 19 years was 0.2 percent, 0.2 percent if the parents were also free of diabetes mellitus and 0.3 percent if childhood insulin was also less than the 75th percentile," the authors write.

"Our data have practical clinical value in assessment of pre-teenaged and teenaged children, since children with systolic blood pressure, triglyceride, body mass index and insulin in the top fifth percentile, a glucose concentration of at least 100 milligrams per deciliter and a parent with diabetes could be targeted for primary prevention of type 2 diabetes mellitus through diet, exercise and possibly insulin-sensitizing drug intervention, with special focus on overweight children with positive family history of diabetes mellitus," they conclude.

This research was supported in part by grants from the National Institutes of Health, the American Heart Association, by the Taft Research Fund and by the Lipoprotein Research Fund of the Jewish Hospital of Cincinnati.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. John A. Morrison; Charles J. Glueck; Paul S. Horn; Ping Wang. Childhood Predictors of Adult Type 2 Diabetes at 9- and 26-Year Follow-ups. Arch Pediatr Adolesc Med, 2010; 164 (1): 53-60 [link]

Cite This Page:

JAMA and Archives Journals. "Childhood metabolic measurements may predict diabetes development years later." ScienceDaily. ScienceDaily, 5 January 2010. <www.sciencedaily.com/releases/2010/01/100104161754.htm>.
JAMA and Archives Journals. (2010, January 5). Childhood metabolic measurements may predict diabetes development years later. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2010/01/100104161754.htm
JAMA and Archives Journals. "Childhood metabolic measurements may predict diabetes development years later." ScienceDaily. www.sciencedaily.com/releases/2010/01/100104161754.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins