Featured Research

from universities, journals, and other organizations

New molecular mechanism discovered that guides visual nerves towards brain

Date:
January 9, 2010
Source:
Institut de recherches cliniques de Montreal
Summary:
Scientists have discovered a new molecular mechanism that permits the guidance of visual nerves towards the brain.

The laboratory of Dr. Frédéric Charron, a researcher at the Institut de recherches cliniques de Montréal (IRCM), has discovered a new molecular mechanism that permits the guidance of visual nerves towards the brain. Their findings have been published in the current issue of the Journal of Neuroscience. The research was conducted in collaboration with Dr. Tomomi Shimogori from the RIKEN Brain Science Institute, in Japan. Pierre Fabre, a doctoral student in Dr. Charron's research unit, is the article's first author.

Related Articles


To correctly establish nervous circuits, attractive and repulsive molecules are required to guide growing axons to their appropriate targets. One such molecule is Sonic Hedgehog (Shh). "Using genetic evidence and in utero manipulations in mice, we were able to demonstrate that the Sonic Hedgehog (Shh) molecular pathway is required for the guidance of retinal axons within the optic chiasm," specified Pierre Fabre. This guidance, which acts through repulsion, relies on the Boc receptor, which becomes therefore a prime target for the development of therapies that could stimulate axonal growth after injury or in neurodegenerative disorders.

Moreover, the authors have shed new light on the molecular mechanisms involved in the formation of the visual system. The optic chiasm is the crossroad of optic nerves stemming from both eyes and allows the brain to integrate binocular visual information, a crucial process for establishing 3D vision. "By showing that Boc and Shh play an important role in this neurobiological development process, we have identified a new molecular pathway required in the formation of the visual system," added Dr. Charron.

"CIHR is proud to support research such as Dr. Charron's, which will improve our understanding of visual development," says Dr. Anthony Phillips, Scientific Director of the Canadian Institutes of Health Research (CIHR) Institute of Neurosciences, Mental Health and Addiction. "The discovery of the new molecular mechanism will pave the way for research into neurodegenerative disorders and, eventually, treatment."

This work was supported by grants from the Canadian Institutes of Health Research (CIHR), the Peter Lougheed Medical Research Foundation, the Fonds de recherche en santé du Québec (FRSQ) and the Canada Foundation for Innovation (CFI). Pierre Fabre was also awarded scholarships from the Université de Montréal and the IRCM.


Story Source:

The above story is based on materials provided by Institut de recherches cliniques de Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fabre et al. Segregation of Ipsilateral Retinal Ganglion Cell Axons at the Optic Chiasm Requires the Shh Receptor Boc. Journal of Neuroscience, 2010; 30 (1): 266 DOI: 10.1523/JNEUROSCI.3778-09.2010

Cite This Page:

Institut de recherches cliniques de Montreal. "New molecular mechanism discovered that guides visual nerves towards brain." ScienceDaily. ScienceDaily, 9 January 2010. <www.sciencedaily.com/releases/2010/01/100107114436.htm>.
Institut de recherches cliniques de Montreal. (2010, January 9). New molecular mechanism discovered that guides visual nerves towards brain. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/01/100107114436.htm
Institut de recherches cliniques de Montreal. "New molecular mechanism discovered that guides visual nerves towards brain." ScienceDaily. www.sciencedaily.com/releases/2010/01/100107114436.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins