Featured Research

from universities, journals, and other organizations

Abnormal blood calcium levels deadly for kidney disease patients

Date:
January 8, 2010
Source:
American Society of Nephrology
Summary:
Abnormally high or low blood calcium levels are linked to an increased chance of premature death in non-dialysis kidney disease patients, according to a new study. The findings indicate the potential importance of finding drugs or other treatments that maintain normal blood calcium levels in non-dialysis patients.

Abnormally high or low blood calcium levels are linked to an increased chance of premature death in non-dialysis kidney disease patients, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate the potential importance of finding drugs or other treatments that maintain normal blood calcium levels in non-dialysis patients.

Related Articles


Patients with chronic kidney disease (CKD) often have abnormally high or low blood calcium levels due to their compromised kidney function and the effects of commonly used medications. While abnormal calcium levels have been linked to higher premature death rates in dialysis patients, their effects in patients with earlier stages of CKD are less clear.

To investigate the issue, Csaba Kovesdy, MD (Salem VA Medical Center), and his colleagues examined the death rates associated with various blood calcium levels in 1,243 male US veterans with moderate-to-advanced CKD not requiring dialysis therapy. During the study, abnormally high calcium levels were linked to higher death rates among patients particularly when high calcium levels were present for a prolonged period of time. Specifically, compared with patients with normal blood calcium levels, patients with abnormally high levels had a 31% increased risk of dying during the study. Low calcium levels were also linked to higher death rates, but after much shorter periods of exposure to such levels. These patients had a 21% increased risk of dying.

The authors speculate that high calcium levels may be involved in processes that take a longer time to cause harm, such as the calcification of blood vessels or soft tissues, while low calcium levels may cause short-term deleterious effects such as heart rhythm abnormalities. The authors also noted that while their observations suggest that maintaining normal blood calcium levels is beneficial for non-dialysis CKD patients, prospective studies are needed to determine the target range for blood calcium and how such a target should be achieved.

Study co-authors include Olga Kuchmak, MD (Carilion Clinic), Jun Lu, MD (Salem Research Institute), and Kamyar Kalantar-Zadeh, MD PhD (Harbor-UCLA Medical Center and David Geffen School of Medicine at UCLA). Dr. Kovesdy and Dr. Kalantar-Zadeh have received grant support and/or honoraria from Fresenius, Genzyme and Shire. The other authors report no financial disclosures.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Csaba P. Kovesdy, Olga Kuchmak, Jun L. Lu, and Kamyar Kalantar-Zadeh. Outcomes Associated with Serum Calcium Level in Men with Non-Dialysis Dependent Chronic Kidney Disease. Clinical Journal of the American Society Nephrology, Jan. 7, 2010 DOI: 10.2215/CJN.06040809

Cite This Page:

American Society of Nephrology. "Abnormal blood calcium levels deadly for kidney disease patients." ScienceDaily. ScienceDaily, 8 January 2010. <www.sciencedaily.com/releases/2010/01/100107183030.htm>.
American Society of Nephrology. (2010, January 8). Abnormal blood calcium levels deadly for kidney disease patients. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2010/01/100107183030.htm
American Society of Nephrology. "Abnormal blood calcium levels deadly for kidney disease patients." ScienceDaily. www.sciencedaily.com/releases/2010/01/100107183030.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins