Featured Research

from universities, journals, and other organizations

Blood test may aid in lung cancer diagnosis and reduce unnecessary invasive procedures

Date:
January 15, 2010
Source:
American Association for Cancer Research
Summary:
Of the nearly 150,000 abnormal chest X-rays performed each year in the United States, 25 percent of patients will display only benign lung pathologies on further surgical examination.

Of the nearly 150,000 abnormal chest X-rays performed each year in the United States, 25 percent of patients will display only benign lung pathologies on further surgical examination.

This false-positive rate has important clinical implications in cost and side effects. A recent report in the Annals of Internal Medicine showed that CT scans, often used as a follow-up to X-rays, were linked to cancer because of their high doses of radiation.

Steven Dubinett, M.D., professor of medicine and pathology, and director of the Lung Cancer Research Program at the Jonsson Comprehensive Cancer Center at the David Geffen School of Medicine, University of California, Los Angeles, said that while findings regarding the detrimental effects of imaging studies like CT scanning are still somewhat controversial, the need for more accurate testing is not.

In a study presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer, Dubinett and colleagues assembled a 40-marker panel of potential lung cancer biomarkers based on previous investigations from 90 patients with lung cancer as well as 56 control patients thought to be at high risk due to their smoking histories.

"The diagnosis of an indeterminate pulmonary lesion can be difficult, and current methods for confirming an abnormal imaging study include invasive procedures for biopsies," said Dubinett. "We anticipate that in the future, blood tests will be clinically relevant and lead to reduced use of more invasive diagnostic measures."

Based on statistical analysis, the researchers identified a 40-biomarker panel that correctly identified patients with lung cancer 88 percent of the time, which scientists call sensitivity. Furthermore, the test correctly identified patients who did not have lung cancer 79 percent of the time, what researchers call specificity.

Dubinett stressed that these findings are preliminary and would not reach the clinic for several years, but the fact that 21 of these biomarkers in the 40-biomarker panel were significantly different between patients with stage I non-small cell lung cancer and controls suggests promise for this type of test.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Blood test may aid in lung cancer diagnosis and reduce unnecessary invasive procedures." ScienceDaily. ScienceDaily, 15 January 2010. <www.sciencedaily.com/releases/2010/01/100112165106.htm>.
American Association for Cancer Research. (2010, January 15). Blood test may aid in lung cancer diagnosis and reduce unnecessary invasive procedures. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2010/01/100112165106.htm
American Association for Cancer Research. "Blood test may aid in lung cancer diagnosis and reduce unnecessary invasive procedures." ScienceDaily. www.sciencedaily.com/releases/2010/01/100112165106.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins