Featured Research

from universities, journals, and other organizations

A paracrine pathway regulates pancreatic cancer cell invasion

Date:
January 15, 2010
Source:
Journal of the National Cancer Institute
Summary:
Pancreatic cancer cell invasion along nerves is regulated by a paracrine pathway that involves glial cell-derived neurotrophic factor, which may be a possible target for preventing the invasion, according to a new study.

Pancreatic cancer cell invasion along nerves is regulated by a paracrine pathway that involves glial cell-derived neurotrophic factor, which may be a possible target for preventing the invasion, according to a new study published online January 12 in the Journal of the National Cancer Institute.

To better understand how pancreatic cancer cells infiltrate nerve cells, Ziv Gil, M.D., Ph.D., of the department of otolaryngology, head and neck surgery, at Tel Aviv Sourasky Medical Center in Israel, and colleagues used an in vitro Matrigel dorsal root ganglion and pancreatic cancer cell coculture model to assess the interaction between nerves and cancer cell migration, as well as the role of glial cell-derived neurotrophic factor.

The researchers found that the migration of tumor cells along nerves was more rapid than that in the absence of nerves, and the secretion of glial cell-derived neurotrophic factor induced the migration. Mice treated with an inhibitor of the pathway had reduced nerve invasion. Also, tumors from patients with pancreatic cancer that had invaded nerves expressed more factor receptors than normal tissue.

The authors write: "Treatment directed against neural invasion could theoretically prevent the local extension of cancer to the central nervous system, preserve nerve function, reduce neuropathic pain, and prolong survival. Such treatment might, in the future, be offered as an adjuvant therapy to enhance conventional therapy for pancreatic cancer."

Study limitations: The generalizability of the findings of the mouse and tissue culture to human disease is unknown. The in vitro and in vivo models used did not encompass all of the possible interactions between cancer cells and nerves.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "A paracrine pathway regulates pancreatic cancer cell invasion." ScienceDaily. ScienceDaily, 15 January 2010. <www.sciencedaily.com/releases/2010/01/100112165242.htm>.
Journal of the National Cancer Institute. (2010, January 15). A paracrine pathway regulates pancreatic cancer cell invasion. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/01/100112165242.htm
Journal of the National Cancer Institute. "A paracrine pathway regulates pancreatic cancer cell invasion." ScienceDaily. www.sciencedaily.com/releases/2010/01/100112165242.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins