Featured Research

from universities, journals, and other organizations

Minimal changes alter an enzyme dramatically

Date:
January 19, 2010
Source:
Uppsala Universitet
Summary:
New functions can develop in an enzyme, according to new research. This can explain, for example, how resistance to toxins can occur so simply.

A new study by a research team at Uppsala University shows how new functions can develop in an enzyme. This can explain, for example, how resistance to toxins can occur so simply. The findings are now being published in the Journal of Biological Chemistry.

Every biological being needs a large number of enzymes for the many functions of cells. In the spirit of Darwin, enzymes in an organism can change over time to meet new needs. This is done by alterations in the enzymes' building blocks that are caused by mutations in the DNA.

The new study, directed by Professor Bengt Mannervik, shows that new functions can develop in an enzyme through point mutation, that is, a single one of the enzyme's building blocks is deleted or replaced. The findings may explain how resistance to toxins can simply emerge without any major structural alterations of a gene.

"The findings are important for the development of resistance in insects to pesticides, in viruses and bacteria to drugs, and in tumors to chemotherapy," explains Bengt Mannervik.


Story Source:

The above story is based on materials provided by Uppsala Universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shokeer et al. Minor Modifications of the C-Terminal Helix Reschedule the Favored Chemical Reactions Catalyzed by Theta Class Glutathione Transferase. Journal of Biological Chemistry, 2009; DOI: 10.1074/jbc.M109.074757

Cite This Page:

Uppsala Universitet. "Minimal changes alter an enzyme dramatically." ScienceDaily. ScienceDaily, 19 January 2010. <www.sciencedaily.com/releases/2010/01/100119074759.htm>.
Uppsala Universitet. (2010, January 19). Minimal changes alter an enzyme dramatically. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2010/01/100119074759.htm
Uppsala Universitet. "Minimal changes alter an enzyme dramatically." ScienceDaily. www.sciencedaily.com/releases/2010/01/100119074759.htm (accessed April 23, 2014).

Share This



More Plants & Animals News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins