Featured Research

from universities, journals, and other organizations

Minimal changes alter an enzyme dramatically

Date:
January 19, 2010
Source:
Uppsala Universitet
Summary:
New functions can develop in an enzyme, according to new research. This can explain, for example, how resistance to toxins can occur so simply.

A new study by a research team at Uppsala University shows how new functions can develop in an enzyme. This can explain, for example, how resistance to toxins can occur so simply. The findings are now being published in the Journal of Biological Chemistry.

Related Articles


Every biological being needs a large number of enzymes for the many functions of cells. In the spirit of Darwin, enzymes in an organism can change over time to meet new needs. This is done by alterations in the enzymes' building blocks that are caused by mutations in the DNA.

The new study, directed by Professor Bengt Mannervik, shows that new functions can develop in an enzyme through point mutation, that is, a single one of the enzyme's building blocks is deleted or replaced. The findings may explain how resistance to toxins can simply emerge without any major structural alterations of a gene.

"The findings are important for the development of resistance in insects to pesticides, in viruses and bacteria to drugs, and in tumors to chemotherapy," explains Bengt Mannervik.


Story Source:

The above story is based on materials provided by Uppsala Universitet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shokeer et al. Minor Modifications of the C-Terminal Helix Reschedule the Favored Chemical Reactions Catalyzed by Theta Class Glutathione Transferase. Journal of Biological Chemistry, 2009; DOI: 10.1074/jbc.M109.074757

Cite This Page:

Uppsala Universitet. "Minimal changes alter an enzyme dramatically." ScienceDaily. ScienceDaily, 19 January 2010. <www.sciencedaily.com/releases/2010/01/100119074759.htm>.
Uppsala Universitet. (2010, January 19). Minimal changes alter an enzyme dramatically. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/01/100119074759.htm
Uppsala Universitet. "Minimal changes alter an enzyme dramatically." ScienceDaily. www.sciencedaily.com/releases/2010/01/100119074759.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Dinosaur Species Found in Museum Collection

New Dinosaur Species Found in Museum Collection

Reuters - Innovations Video Online (Nov. 27, 2014) A British palaeontologist has discovered a new species of dinosaur while studying fossils in a Canadian museum. Pentaceratops aquilonius was related to Triceratops and lived at the end of the Cretaceous Period, around 75 million years ago. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins