Featured Research

from universities, journals, and other organizations

How anticancer immune responses are suppressed

Date:
January 25, 2010
Source:
Journal of Clinical Investigation
Summary:
Immune cells known as myeloid-derived suppressor cells (MDSCs) keep other immune cells in check. They have been found to accumulate in individuals with cancer, where they are thought to contribute to tumor development. Researchers have now identified a molecular pathway that enhances the immunosuppressive functions of tumor-associated mouse and human MDSCs.

Immune cells known as myeloid-derived suppressor cells (MDSCs) keep other immune cells in check. They have been found to accumulate in individuals with cancer, where they are thought to contribute to tumor development.

Franηois Ghiringhelli and colleagues, at INSERM U866, Dijon, France, have now identified a molecular pathway that enhances the immunosuppressive functions of tumor-associated mouse and human MDSCs.

In the study, tiny vesicles known as exosomes released by human and mouse tumor cells were found to have the molecule Hsp72 on their surface. This bound the protein TLR2 on human and mouse MDSCs, triggering a signaling pathway that resulted in enhanced MDSC suppressive function. Importantly, decreasing tumor exosome release pharmacologically in vivo enhanced the antitumor effects of the chemotherapeutic drug cyclophosphamide in three different mouse models of cancer.

The authors therefore suggest that drugs that prevent tumor exosome release might be beneficial to cancer patients being treated with conventional chemotherapeutic drugs.

The research appears in the Journal of Clinical Investigation.



Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chalmin et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40483

Cite This Page:

Journal of Clinical Investigation. "How anticancer immune responses are suppressed." ScienceDaily. ScienceDaily, 25 January 2010. <www.sciencedaily.com/releases/2010/01/100119224803.htm>.
Journal of Clinical Investigation. (2010, January 25). How anticancer immune responses are suppressed. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2010/01/100119224803.htm
Journal of Clinical Investigation. "How anticancer immune responses are suppressed." ScienceDaily. www.sciencedaily.com/releases/2010/01/100119224803.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) — A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) — That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) — Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) — The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins