Featured Research

from universities, journals, and other organizations

Inflammation marker related to obesity is elevated in patients with pancreatic cancer

Date:
February 18, 2010
Source:
Thomas Jefferson University
Summary:
The levels of an inflammatory chemokine were significantly elevated in patients with pancreatic cancer who were extremely obese, according to new research.

The levels of an inflammatory chemokine were significantly elevated in patients with pancreatic cancer who were extremely obese, according to research conducted by scientists at the Jefferson Pancreatic, Biliary and Related Cancers Center. They presented their data at the 5th Annual Academic Surgical Congress, held in San Antonio.

Related Articles


Studies have shown that obesity is correlated with inflammation. Similarly, studies have also shown that inflammation contributes to the tumor progression of pancreatic ductal adenocarcinoma (PDA). This study looks at the role of monocyte chemoattractant protein-1 (MCP-1), a marker of inflammation, in obese patients with pancreatic cancer.

Hwyda Arafat, M.D., Ph.D., associate professor of Surgery at Jefferson Medical College of Thomas Jefferson University, and colleagues sought to identify whether MCP-1 could serve as a marker for pancreatic cancer, and a differentiation marker between benign and malignant lesions.

The research team analyzed the MCP-1 levels in serum samples obtained from patients with confirmed PDA or intraductal papillary mucinous neoplasms (IPMN). They found that the levels of MCP-1 were significantly elevated in extremely obese patients. In the less obese population (BMI < 37.5), the MCP-1 levels were elevated only in patients with PDA. In the patients who had IPMN, high levels of MCP-1 also correlated with older age.

"MCP-1 has potential as a biomarker for pancreatic cancer, but this needs to be confirmed in a larger sample size," Dr. Arafat said. "Further study of this protein in a larger sample size and different benign and unresectable malignant lesions is needed. Understanding the nature of the relationship of its elevation with age and the highest levels of obesity will assist with the full development of the potential clinical usage of this marker."

The study will be presented by first author Jennifer Sullivan, a former resident in Dr. Arafat's lab. Terry Hyslop, Ph.D., Director of the Division of Biostatistics, and Charles Yeo, M.D., the Samuel D. Gross Professor and Chairman of Surgery, also participated in the study.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Inflammation marker related to obesity is elevated in patients with pancreatic cancer." ScienceDaily. ScienceDaily, 18 February 2010. <www.sciencedaily.com/releases/2010/02/100203121544.htm>.
Thomas Jefferson University. (2010, February 18). Inflammation marker related to obesity is elevated in patients with pancreatic cancer. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2010/02/100203121544.htm
Thomas Jefferson University. "Inflammation marker related to obesity is elevated in patients with pancreatic cancer." ScienceDaily. www.sciencedaily.com/releases/2010/02/100203121544.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins