Featured Research

from universities, journals, and other organizations

Prolactin blocks oncogene associated with poor prognosis in breast cancer

Date:
February 4, 2010
Source:
Thomas Jefferson University
Summary:
Researchers have found a mechanism by which a hormone responsible for milk production blocks an oncogene that makes breast cancer more aggressive.

Researchers from the Kimmel Cancer Center at Jefferson have found a mechanism by which a hormone responsible for milk production blocks an oncogene that makes breast cancer more aggressive.

Publishing in the journal Cancer Research, the researchers discovered that prolactin, a pituitary hormone that normally stimulates breast development and milk production, in fact reduces levels of an oncogene called BCL6. The BCL6 protein has previously been shown to play a role in poorly differentiated breast cancer, which carries a poorer prognosis.

According to Hallgeir Rui, M.D., Ph.D., a professor of Cancer Biology and Medical Oncology at Jefferson Medical College of Thomas Jefferson University, prolactin's role in breast cancer is, to a large extent, carried out by a protein pathway called Stat5. In breast cancer, the inactivation of Stat5 is related to poorly differentiated breast cancer, and thus poorer prognosis.

"We found that prolactin will block expression of the BCL6 protein, and showed that Stat5a, but not the very similar Stat5b variant, is involved in this process as a mediator of prolactin," said Dr. Rui. "We think that prolactin plays an important role in preventing aggressive breast cancers, and that there is a connection between the loss of Stat5 and the increase of BCL6 in making breast cancer more aggressive."

Dr Rui and his laboratory investigated the phenomenon in several different breast cancer cell lines grown in the laboratory, and also in mice and in human breast cancer samples. The relationship held up across all three.

Receptors for prolactin are present on a majority of breast cancers. Prolactin levels in blood are relatively unaffected by menopause, and breast cancer patients across all age groups are exposed to the hormone. The new findings may lead to better diagnostic tests for breast cancer, and also the development of new treatments.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Prolactin blocks oncogene associated with poor prognosis in breast cancer." ScienceDaily. ScienceDaily, 4 February 2010. <www.sciencedaily.com/releases/2010/02/100203121548.htm>.
Thomas Jefferson University. (2010, February 4). Prolactin blocks oncogene associated with poor prognosis in breast cancer. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2010/02/100203121548.htm
Thomas Jefferson University. "Prolactin blocks oncogene associated with poor prognosis in breast cancer." ScienceDaily. www.sciencedaily.com/releases/2010/02/100203121548.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins