Featured Research

from universities, journals, and other organizations

Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction

Date:
February 25, 2010
Source:
American Society for Radiation Oncology
Summary:
Head and neck cancer patients receiving induction chemotherapy followed by radiation to preserve their larynx have a low-risk of severe voice disability and almost half experienced no eating or swallowing problems, according to a first of its kind study.

Head and neck cancer patients receiving induction chemotherapy followed by radiation to preserve their larynx have a low-risk of severe voice disability and almost half experienced no eating or swallowing problems, according to a first of its kind study presented at the Multidisciplinary Head and Neck Cancer Symposium, sponsored by AHNS, ASCO, ASTRO and SNM.

Total larynx removal with permanent tracheotomy is the current standard treatment for patients with cancer of the larynx. While larynx preservation using chemotherapy followed by radiation is an effective treatment, the functional results are often not reported and the quality of life for these patients unknown.

Researchers at the Hopital Bretonneau in Tours, France, the Centre Hospitalier in Lorient, France, the Centre Paul Papin in Angers, France, the Institut Gustave Roussy in Villejuif, France, and the Institut Sainte Catherine in Avignon, France, observed 213 patients who received induction chemotherapy using Ciplatin and 5FU without (PF) or with Docetaxel (TPF) followed by radiation and evaluated the quality of the voice, the nutritional function and the quality of life.

After 61 months of follow up, the laryngo-esophageal dysfunction free-survival was 28 percent when averaging the PF arm and the TPF arm. Voice disability was low for 57 percent of patients, with only 15 percent experiencing severe voice disability. Forty percent of patients had no eating or swallowing problems at all and 8 percent required a feeding tube.

"For cancer patients receiving treatment to their larynx, it is important to preserve the organ, but it is more important to preserve the function of this organ," Gilles Calais, M.D., lead author of the study and a radiation oncologist at the Hopital Bretonneau in Tours, France, said. "This is the first study that analyzes not only the preservation rate but also the preservation of the function of the larynx and the esophagus."

The abstract, "Induction Chemotherapy Followed by Radiation for Larynx preservation. Functional Results of the Gortec 2000-01 Randomized Trial," was presented in the plenary session on February 25, 2010.


Story Source:

The above story is based on materials provided by American Society for Radiation Oncology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Radiation Oncology. "Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction." ScienceDaily. ScienceDaily, 25 February 2010. <www.sciencedaily.com/releases/2010/02/100225140854.htm>.
American Society for Radiation Oncology. (2010, February 25). Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2010/02/100225140854.htm
American Society for Radiation Oncology. "Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction." ScienceDaily. www.sciencedaily.com/releases/2010/02/100225140854.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins