Featured Research

from universities, journals, and other organizations

Novel way to study human inflammatory disease

Date:
February 28, 2010
Source:
University of Colorado at Boulder
Summary:
A new study shows mice infected with the bacteria salmonella develop clinical signs consistent with a deadly and poorly understood human inflammatory disease, a finding that may lead to new therapies.

A new University of Colorado at Boulder study shows mice infected with the bacteria salmonella develop clinical signs consistent with a deadly and poorly understood human inflammatory disease, a finding that may lead to new therapies.

The human disease, known as Hemophagocytic Lymphohistiocytosis, or HLH, is a rare inflammatory disease that kills between 50 percent and 90 percent of its victims, said Diane Brown, lead author of the study. HLH treatment may require bone marrow transplantation, a drastic therapy with life-long consequences, according to Brown, adjoint curator at the University of Colorado Museum of Natural History.

The disease, in which the immune system becomes hyperactivated, occurs both in an inherited form, known as primary HLH, and in people with no known genetic defect, known as secondary HLH. Both forms are usually triggered by infections. The genetic form of HLH most often strikes infants and very young children.

A paper on the subject is being published Feb. 26 in PLoS One, a journal of the Public Library of Science. Study co-authors, all from CU-Boulder's molecular, cellular and developmental biology department, included Assistant Professor Corrella Detweiler, postdoctoral fellows Melissa McCoy and Carolina Pilonieta, and former master's student Rebecca Nix, now at Supergen in Salt Lake City.

Salmonella is a well-known food contaminant, causing a variety of gastrointestinal tract symptoms in humans. While mice infected with salmonella are spared the cramping and diarrhea that humans develop, they were shown to develop a disease syndrome comparable to human secondary HLH, said Brown.

The CU-Boulder research team found that mice infected with salmonella developed fever, enlarged spleens, anemia, reduced numbers of platelets, dangerously high blood levels of an iron-storage protein, and neurological signs. In addition, specialized white blood cells known as hemophagocytic macrophages accumulated in the organs of the body, including bone marrow.

The team previously showed that salmonella-infected mice developed hemophagocytic macrophages, which ingest other white and red blood cells. "These earlier findings helped lead us down the current research path," said Detweiler.

"One part of this study is to try to use our research to understand how anemia develops in these infected mice, which might help us understand how symptoms of HLH develop," said Detweiler. The syndrome can be difficult to recognize and diagnose, she added.

"The availability of this animal model for HLH will help to advance the research and understanding of the underlying mechanisms of this immune system disorder," said Detweiler. "It also should provide a means to test new therapies for HLH."

The study was funded by the National Institutes of Health and the American Recovery and Relief Act.


Story Source:

The above story is based on materials provided by University of Colorado at Boulder. Note: Materials may be edited for content and length.


Cite This Page:

University of Colorado at Boulder. "Novel way to study human inflammatory disease." ScienceDaily. ScienceDaily, 28 February 2010. <www.sciencedaily.com/releases/2010/02/100225214812.htm>.
University of Colorado at Boulder. (2010, February 28). Novel way to study human inflammatory disease. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2010/02/100225214812.htm
University of Colorado at Boulder. "Novel way to study human inflammatory disease." ScienceDaily. www.sciencedaily.com/releases/2010/02/100225214812.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins