Featured Research

from universities, journals, and other organizations

Nephrology: Kidney diseases linked to the cellular process autophagy

Date:
March 1, 2010
Source:
Journal of Clinical Investigation
Summary:
A leading contributor to the development of both diseases that affect a structure in the kidney known as the glomerulus (glomerular diseases) and kidney failure is injury and loss of kidney cells known as podocytes. New research has now determined that podocyte integrity in mice is maintained by the cellular process autophagy.

A leading contributor to the development of both diseases that affect a structure in the kidney known as the glomerulus (glomerular diseases) and kidney failure is injury and loss of kidney cells known as podocytes.

New research, performed by Tobias Huber and colleagues, at University Hospital Freiburg, Germany, has now determined that podocyte integrity in mice is maintained by the cellular process autophagy.

In the study, mouse podocytes were found to naturally undergo high levels of autophagy. Furthermore, deletion of the gene autophagy-related 5 in podocytes led to podocyte loss and glomerular disease in aging mice and to increased susceptibility to models of glomerular disease in young mice.

The authors therefore suggest that autophagy helps protect against podocyte aging and glomerular injury and that it could be targeted to reduce human glomerular disease and aging-related loss of kidney function.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. björn Hartleben, Markus Gödel, Catherine Meyer-Schwesinger, Shuya Liu, Theresa Ulrich, Sven Köbler, Thorsten Wiech, Florian Grahammer, Sebastian J. Arnold, Maja T. Lindenmeyer, Clemens D. Cohen, Hermann Pavenstädt, Dontscho Kerjaschki, Noboru Mizushima, Andrey S. Shaw, Gerd Walz, and Tobias B. Huber. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI39492

Cite This Page:

Journal of Clinical Investigation. "Nephrology: Kidney diseases linked to the cellular process autophagy." ScienceDaily. ScienceDaily, 1 March 2010. <www.sciencedaily.com/releases/2010/03/100301212253.htm>.
Journal of Clinical Investigation. (2010, March 1). Nephrology: Kidney diseases linked to the cellular process autophagy. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/03/100301212253.htm
Journal of Clinical Investigation. "Nephrology: Kidney diseases linked to the cellular process autophagy." ScienceDaily. www.sciencedaily.com/releases/2010/03/100301212253.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) — The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins