Featured Research

from universities, journals, and other organizations

Freezing breast tumors helps stop cancer’s spread in mice, study finds

Date:
March 3, 2010
Source:
University of Michigan Health System
Summary:
Freezing a cancer kills it in its place, and also appears to generate an immune response that helps stop the cancer's spread, leading to improved survival rates over surgery, according to a new study in mice.

Freezing a cancer kills it in its place, and also appears to generate an immune response that helps stop the cancer's spread, leading to improved survival rates over surgery, according to a new study in mice from researchers at the University of Michigan Comprehensive Cancer Center.

Researchers looked at two different cryoablation techniques, which both involve applying a cold probe to a tumor to freeze it. The study was done in mice with breast cancer. One method involves freezing the tumor rapidly, in about 30 seconds; the other freezes the tumor slowly, taking a few minutes. Results from the cryoablation were compared to results from mice whose tumors were removed with surgery.

Both cryoablation techniques successfully killed the breast tumor. The mice treated with the rapid freeze had fewer tumors that spread to the lungs and improved survival compared to mice treated with surgery alone or mice treated with the slower freezing technique. The study showed that the benefit from the rapid freezing is likely due to changes in the immune system that help to kill the tumor. Freezing with the slower technique appeared to make the immune system not as able to kill the tumor.

The study appears online in Annals of Surgical Oncology. Based on these results from mice, researchers are now conducting a clinical trial using cryoablation in patients with breast cancer. In this trial, researchers use the rapid freezing technique.

"Cryoablation has strong potential as a treatment for breast cancer. Not only does it appear effective in treating the primary tumor with little cosmetic concerns, but it also may stimulate an immune response capable of eradicating any cells that have traveled throughout the body, reducing both local and distant recurrence, similar to giving a breast cancer vaccine," says lead study author Michael Sabel, M.D., associate professor of surgery at the U-M Medical School.

"What we learned in this study is that all cryoablation is not equal. The technique used to freeze the tissue can have a significant impact on how the immune system responds. The system we use today appears to be ideal for both destroying the tumor within the breast and generating an anti-cancer immune response," Sabel says.

U-M researchers are participating in a national clinical trial to evaluate using cryoablation for early stage breast cancer. Participants will undergo rapid freezing of their tumor, and their blood samples will be analyzed to assess changes in their immune system. All participants will be treated three to four weeks later with standard surgery to remove their tumor.

Cryoablation is currently used routinely for prostate cancer, kidney cancer and a variety of cancers that have spread to the liver and bone.

Breast cancer statistics:

192,280 Americans will be diagnosed with breast cancer this year and 40,610 will die from the disease, according to the American Cancer Society


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sabel et al. Rate of Freeze Alters the Immunologic Response After Cryoablation of Breast Cancer. Annals of Surgical Oncology, 2009; DOI: 10.1245/s10434-009-0846-1

Cite This Page:

University of Michigan Health System. "Freezing breast tumors helps stop cancer’s spread in mice, study finds." ScienceDaily. ScienceDaily, 3 March 2010. <www.sciencedaily.com/releases/2010/03/100303092403.htm>.
University of Michigan Health System. (2010, March 3). Freezing breast tumors helps stop cancer’s spread in mice, study finds. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2010/03/100303092403.htm
University of Michigan Health System. "Freezing breast tumors helps stop cancer’s spread in mice, study finds." ScienceDaily. www.sciencedaily.com/releases/2010/03/100303092403.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins