Featured Research

from universities, journals, and other organizations

Aluminum adjuvants in vaccinations: How do they really work?

Date:
April 14, 2010
Source:
Keele University
Summary:
An new article by a leading researcher in the bioinorganic chemistry of aluminum explains how aluminum adjuvants work in boosting the immune response to vaccination.

A new article in Trends in Immunology by a leading researcher in the bioinorganic chemistry of aluminum, Keele University's Dr. Christopher Exley, explains how aluminum adjuvants work in boosting the immune response to vaccination.

Adjuvants are used in vaccinations to improve the efficacy of the vaccine. They enhance the immune response to the vaccine. For almost 80 years the most common form of clinically approved adjuvant has been aluminum salts. They are used in the majority of vaccines today including vaccines against cervical cancer (HPV), hepatitis, polio, tetanus, diptheria and seasonal flu amongst many others. In spite of the widespread use of aluminum-based adjuvants there is very little understanding of how they actually work.

A recent flurry of research papers purported to explain their mode of action though it quickly became clear that the story was still significantly confused.

The opinion article by Exley -- Reader in Bioinorganic Chemistry at The Birchall Centre, Keele University in Staffordshire -- in the review journal has explained the likely mode of action of aluminum adjuvants in the context of both the bioinorganic chemistry and immunobiology of aluminum. It has helped to explain why previous suggestions as how aluminum adjuvants work are probably not applicable to the clinically approved aluminum adjuvants used in human vaccination programs.

In doing so, the article highlights the potential for aluminum and aluminum salts to stimulate the immune system and makes some reference to the possible role of aluminum adjuvants in vaccine-related diseases. The latter, though their etiologies are largely unexplained, seem often to be linked to aluminum adjuvants.


Story Source:

The above story is based on materials provided by Keele University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher Exley, Peter Siesjφ, and Hεkan Eriksson. The immunobiology of aluminium adjuvants: how do they really work? Trends in Immunology, 2010; DOI: 10.1016/j.it.2009.12.009

Cite This Page:

Keele University. "Aluminum adjuvants in vaccinations: How do they really work?." ScienceDaily. ScienceDaily, 14 April 2010. <www.sciencedaily.com/releases/2010/03/100303193113.htm>.
Keele University. (2010, April 14). Aluminum adjuvants in vaccinations: How do they really work?. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2010/03/100303193113.htm
Keele University. "Aluminum adjuvants in vaccinations: How do they really work?." ScienceDaily. www.sciencedaily.com/releases/2010/03/100303193113.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) — An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) — Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Ramen Health Risks: The Dark Side of the Noodle

Ramen Health Risks: The Dark Side of the Noodle

AP (Aug. 21, 2014) — South Koreans eat more instant ramen noodles per capita than anywhere else in the world. But American researchers say eating too much may increase the risk of diabetes, heart disease and stroke. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins