Featured Research

from universities, journals, and other organizations

Aluminum adjuvants in vaccinations: How do they really work?

Date:
April 14, 2010
Source:
Keele University
Summary:
An new article by a leading researcher in the bioinorganic chemistry of aluminum explains how aluminum adjuvants work in boosting the immune response to vaccination.

A new article in Trends in Immunology by a leading researcher in the bioinorganic chemistry of aluminum, Keele University's Dr. Christopher Exley, explains how aluminum adjuvants work in boosting the immune response to vaccination.

Related Articles


Adjuvants are used in vaccinations to improve the efficacy of the vaccine. They enhance the immune response to the vaccine. For almost 80 years the most common form of clinically approved adjuvant has been aluminum salts. They are used in the majority of vaccines today including vaccines against cervical cancer (HPV), hepatitis, polio, tetanus, diptheria and seasonal flu amongst many others. In spite of the widespread use of aluminum-based adjuvants there is very little understanding of how they actually work.

A recent flurry of research papers purported to explain their mode of action though it quickly became clear that the story was still significantly confused.

The opinion article by Exley -- Reader in Bioinorganic Chemistry at The Birchall Centre, Keele University in Staffordshire -- in the review journal has explained the likely mode of action of aluminum adjuvants in the context of both the bioinorganic chemistry and immunobiology of aluminum. It has helped to explain why previous suggestions as how aluminum adjuvants work are probably not applicable to the clinically approved aluminum adjuvants used in human vaccination programs.

In doing so, the article highlights the potential for aluminum and aluminum salts to stimulate the immune system and makes some reference to the possible role of aluminum adjuvants in vaccine-related diseases. The latter, though their etiologies are largely unexplained, seem often to be linked to aluminum adjuvants.


Story Source:

The above story is based on materials provided by Keele University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher Exley, Peter Siesjφ, and Hεkan Eriksson. The immunobiology of aluminium adjuvants: how do they really work? Trends in Immunology, 2010; DOI: 10.1016/j.it.2009.12.009

Cite This Page:

Keele University. "Aluminum adjuvants in vaccinations: How do they really work?." ScienceDaily. ScienceDaily, 14 April 2010. <www.sciencedaily.com/releases/2010/03/100303193113.htm>.
Keele University. (2010, April 14). Aluminum adjuvants in vaccinations: How do they really work?. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2010/03/100303193113.htm
Keele University. "Aluminum adjuvants in vaccinations: How do they really work?." ScienceDaily. www.sciencedaily.com/releases/2010/03/100303193113.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) — A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins