Featured Research

from universities, journals, and other organizations

Novel criteria to differentiate fibrosis from steatohepatitis

Date:
March 5, 2010
Source:
World Journal of Gastroenterology
Summary:

Alcoholic liver disease (ALD) is the most common cause of liver cirrhosis in the Western world. Liver biopsy is currently considered the gold standard for assessing hepatic fibrosis or cirrhosis in these patients. However, it is an invasive procedure, with rare but potentially life-threatening complications and its accuracy is limited due to sampling error.

Related Articles


Transient elastography (FibroScanŽ, FS) is a novel rapid and noninvasive method to assess liver fibrosis via measurement of liver stiffness (LS). Although LS closely correlates with fibrosis stage, it also increases in patients with inflammation (steatohepatitis) which often confounds fibrosis in patients with ALD. Thus, novel criteria are urgently required to determine whether LS is increased due to fibrosis or inflammation.

A research article published on February 28, 2010 in the World Journal of Gastroenterology addresses this question. The research team lead by Dr. Sebastian Mueller from Heidelberg University identified in their recent study novel bedside criteria that allowed the differentiation of cirrhosis from inflammation in patients with ALD.

Their results showed that active inflammation of the liver (steatohepatitis) should be excluded first by blood tests prior to the noninvasive assessment of liver fibrosis by transient elastography. If glutamic oxaloacetic transaminase levels are < 100 U/L, the LS value can identify liver fibrosis and can be used as a diagnostic tool.

These novel criteria probably also hold true for other liver disease.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mueller S, Millonig G, Sarovska L, Friedrich S, Reimann FM, Pritsch M, Eisele S, Stickel F, Longerich T, Schirmacher P, Seitz HK. Increased liver stiffness in alcoholic liver disease: Differentiating fibrosis from steatohepatitis. World Journal of Gastroenterology, 2010; 16 (8): 966 DOI: 10.3748/wjg.v16.i8.966

Cite This Page:

World Journal of Gastroenterology. "Novel criteria to differentiate fibrosis from steatohepatitis." ScienceDaily. ScienceDaily, 5 March 2010. <www.sciencedaily.com/releases/2010/03/100305112207.htm>.
World Journal of Gastroenterology. (2010, March 5). Novel criteria to differentiate fibrosis from steatohepatitis. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2010/03/100305112207.htm
World Journal of Gastroenterology. "Novel criteria to differentiate fibrosis from steatohepatitis." ScienceDaily. www.sciencedaily.com/releases/2010/03/100305112207.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) — The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) — The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins