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Oscillations at odds in the heart

Date:
March 15, 2010
Source:
Rockefeller University Press
Summary:
Researchers show that a classical biological oscillator, the glycolytic oscillator, may increase damage to the heart during acute loss of oxygen (anoxia), and as may occur during ischemia.
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Researchers in Germany show that a classical biological oscillator, the glycolytic oscillator, may increase damage to the heart during acute loss of oxygen (anoxia), and as may occur during ischemia. The study appears online March 15 in the Journal of General Physiology.

Oscillations are important in many biological processes, and life could not exist without them. They play roles in the cell cycle, the heart beat, circadian rhythms, and fertility cycles, to name a few. Although oscillations are vital for normal physiological functions, uncontrolled or irregular oscillations can have harmful effects. This may be true of glycolytic oscillations that occur during anoxia and ischemia in the heart.

Glycolytic oscillations have been studied in the past, but only in artificially induced conditions. Klaus Benndorf and his team from the University of Jena were able to create more clinically relevant conditions by using a technique that allowed a single isolated patch-clamped heart muscle cell to be imaged with fluorescent dyes during severe anoxia.

According to James Weiss and Jun-Hai Yang (UCLA) in a Commentary accompanying the paper, the next step will be to determine whether such metabolic oscillations can be detected during acute ischemia in the intact heart, and if so, whether they play a role in hastening cell death.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ganitkevich, V., V. Mattea, and K. Benndorf. Diffusion of a soluble protein, photoactivatable GFP, through a sensory cilium. J. Gen. Physiol, Feb 2010; 135: 173 - 196. DOI: 10.1085/jgp.200910322

Cite This Page:

Rockefeller University Press. "Oscillations at odds in the heart." ScienceDaily. ScienceDaily, 15 March 2010. <www.sciencedaily.com/releases/2010/03/100315103818.htm>.
Rockefeller University Press. (2010, March 15). Oscillations at odds in the heart. ScienceDaily. Retrieved April 27, 2015 from www.sciencedaily.com/releases/2010/03/100315103818.htm
Rockefeller University Press. "Oscillations at odds in the heart." ScienceDaily. www.sciencedaily.com/releases/2010/03/100315103818.htm (accessed April 27, 2015).

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