Featured Research

from universities, journals, and other organizations

New gateway to treat leukemia and other cancers

Date:
March 27, 2010
Source:
University of Montreal
Summary:
Researchers have discovered a previously hidden channel to attack leukemia and other cancer cells, according to a new study. The findings may change the way doctors treat cancer patients.

Canadian researchers have discovered a previously hidden channel to attack leukemia and other cancer cells, according to a new study published in the Journal of Biological Chemistry. The findings from the Université de Montréal, Maisonneuve-Rosemont Hospital and Université Laval may change the way doctors treat cancer patients.

"We found a gateway, which is present in all humans, that allows anti-cancer agents such as Bleomycin to enter the body so they may reach and attack leukemia cells," says senior author Dindial Ramotar, a professor at the Université de Montréal Faculty of Medicine and a scientist at the affiliated Maisonneuve-Rosemont Hospital.

Dr. Ramotar began testing his theory a full decade ago using baker's yeast, which is remarkably similar to human cells. "Our discovery went from that model system to human cells and will soon reach the bedside through translational therapy," he explains. "We are on the brink of testing patients."

The new gateway (SLC22A16) may be a lifesaver for patients with acute myeloid leukemia (AML), a cancer that affects white blood cells. AML patients are extremely difficult to treat, since most are unresponsive to anticancer remedies. "We can now streamline anti-cancer agents to treat AML," says Dr. Ramotar. "For example, we found the anti-cancer agent Bleomycin has positive results on lymphoma cells derived from patients and depends on the presence of the gateway. That's especially good news, since Bleomycin does not act as an immunosuppressant."

The newly identified gateway, Dr. Ramotar cautions, is only "present in some cell types such as those derived from bone marrow." The channel also does not function in colon and breast cancer making it difficult to treat these patients with Bleomycin, he adds. "We must now examine ways to stimulate the gateway to treat a broad range of cancers using Bleomycin and other drugs."

This study was supported by the Canadian Institutes of Health Research and the National Cancer Institute of Canada.


Story Source:

The above story is based on materials provided by University of Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Aouida et al. The Human Carnitine Transporter SLC22A16 Mediates High Affinity Uptake of the Anticancer Polyamine Analogue Bleomycin-A5. Journal of Biological Chemistry, 2010; 285 (9): 6275 DOI: 10.1074/jbc.M109.046151

Cite This Page:

University of Montreal. "New gateway to treat leukemia and other cancers." ScienceDaily. ScienceDaily, 27 March 2010. <www.sciencedaily.com/releases/2010/03/100325113425.htm>.
University of Montreal. (2010, March 27). New gateway to treat leukemia and other cancers. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2010/03/100325113425.htm
University of Montreal. "New gateway to treat leukemia and other cancers." ScienceDaily. www.sciencedaily.com/releases/2010/03/100325113425.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) — Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins