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Cardiology: Protecting heart muscle cells from death

Date:
April 6, 2010
Source:
Journal of Clinical Investigation
Summary:
A team of researchers has identified a role for the protein connexin 43 in protecting mouse heart muscle cells from death. The team therefore suggest that it might be an attractive target for therapies that help protect cells from injuries that normally result in death, such as the injuries suffered by cells as a result of heart attack.

A team of researchers, led by Uta Hoppe, at the University of Cologne, Germany, has identified a role for the protein connexin 43 in protecting mouse heart muscle cells from death.

The team therefore suggests that it might be an attractive target for therapies that help protect cells from injuries that normally result in death, such as the injuries suffered by cells as a result of heart attack.

Several lines of evidence indicate that the PKC protein and mitoKATP potassium channels in the inner mitochondrial membrane have a central role in protecting cells from death. In the study, connexin 43 was found to be required for mitoKATP activation of PKC. Importantly, this pathway was crucial for protecting mouse heart muscle cells from death.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dennis Rottlaender, Kerstin Boengler, Martin Wolny, Guido Michels, Jeannette Endres-Becker, Lukas J. Motloch, Astrid Schwaiger, Astrid Buechert, Rainer Schulz, Gerd Heusch and Uta C. Hoppe. Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40927

Cite This Page:

Journal of Clinical Investigation. "Cardiology: Protecting heart muscle cells from death." ScienceDaily. ScienceDaily, 6 April 2010. <www.sciencedaily.com/releases/2010/04/100401220406.htm>.
Journal of Clinical Investigation. (2010, April 6). Cardiology: Protecting heart muscle cells from death. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2010/04/100401220406.htm
Journal of Clinical Investigation. "Cardiology: Protecting heart muscle cells from death." ScienceDaily. www.sciencedaily.com/releases/2010/04/100401220406.htm (accessed October 23, 2014).

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