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Harm caused by nicotine withdrawal during intensive care

Date:
April 10, 2010
Source:
BioMed Central
Summary:
Nicotine withdrawal can cause dangerous agitation in intensive care patients. Researchers found that, compared to non-smokers, agitated smokers were more likely to accidentally remove tubes and catheters, require supplemental sedative, analgesic or anti-psychotic medications, or need physical restraints.

Nicotine withdrawal can cause dangerous agitation in intensive care patients. Researchers writing in BioMed Central's open access journal Critical Care found that, compared to non-smokers, agitated smokers were more likely to accidentally remove tubes and catheters, require supplemental sedative, analgesic or anti-psychotic medications, or need physical restraints.

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Damien du Cheyron, from Caen University Hospital, France, worked with a team of researchers to study the effects of nicotine withdrawal in 44 smokers and 100 non-smokers in the hospital's intensive care unit, finding that agitation was twice as common in smokers than controls.

He said, "Agitation was significantly more common in smokers than in non-smokers. These results suggest the need to be aware of nicotine withdrawal syndrome in critically ill patients, and support the need for improved strategies to prevent agitation or treat it earlier."

None of the smokers in the study were allowed nicotine replacement therapy (NRT) during the study period. According to du Cheyron, "NRT remains a controversial topic in intensive care and has been associated with mortality. Due to the serious consequences of withdrawal-induced agitation, including sedation and physical restraint, we suggest that the use of nicotine replacement therapy should be tested by a well-designed, randomized controlled clinical trial in the ICU setting."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zalika Klemenc-Ketis, Janko Kersnik and Stefek Grmec. The effect of carbon dioxide on near-death experiences in out-of-hospital cardiac arrest survivors: a prospective observational study. Critical Care, 2010; (in press) [link]

Cite This Page:

BioMed Central. "Harm caused by nicotine withdrawal during intensive care." ScienceDaily. ScienceDaily, 10 April 2010. <www.sciencedaily.com/releases/2010/04/100408194125.htm>.
BioMed Central. (2010, April 10). Harm caused by nicotine withdrawal during intensive care. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2010/04/100408194125.htm
BioMed Central. "Harm caused by nicotine withdrawal during intensive care." ScienceDaily. www.sciencedaily.com/releases/2010/04/100408194125.htm (accessed October 24, 2014).

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