Featured Research

from universities, journals, and other organizations

Source of recurrent yeast infections in autoimmune syndrome pinpointed

Date:
April 11, 2010
Source:
Rockefeller University
Summary:
Infectious diseases are not always caused by infection. Researchers have revealed that patients who suffer from a rare autoimmune disorder that makes them vulnerable to yeast infections produce antibodies that target and destroy immune-fighting proteins that would otherwise keep yeast in check.

Infectious diseases are not always caused by infection. In work reported in the Journal of Experimental Medicine, researchers at Rockefeller University reveal that patients who suffer from a rare autoimmune disorder that makes them vulnerable to yeast infections produce antibodies that target and destroy immune-fighting proteins that would otherwise keep yeast in check.

In 33 patients with the ailment, known as autoimmune polyendocrine syndrome, or APS-1, researchers led by Jean-Laurent Casanova, head of the Laboratory of Human Genetics of Infectious Diseases, found antibodies that attack a class of immune proteins called cytokines. Although several categories of cytokines exist, the antibodies found circulating in the patients' blood have long been known to protect humans from acute bacterial infections.

"These cytokines, particularly the family comprising interleukin 17A, 17F and 22, have recently been implicated in defending against yeast overgrowth, but this is the first time it has been shown in humans," says Casanova. "The next step is to find genetic mutations in these cytokines in patients with candidiasis, as only this will prove the causal relationship."

The findings pave the way for the treatment of fungal infections in APS-I patients with drugs that are already out in the market. The drugs clear the cytokine-attacking antibodies by depleting the B cells that make them.


Story Source:

The above story is based on materials provided by Rockefeller University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Puel et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. Journal of Experimental Medicine, 2010; 207 (2): 291 DOI: 10.1084/jem.20091983

Cite This Page:

Rockefeller University. "Source of recurrent yeast infections in autoimmune syndrome pinpointed." ScienceDaily. ScienceDaily, 11 April 2010. <www.sciencedaily.com/releases/2010/04/100410140439.htm>.
Rockefeller University. (2010, April 11). Source of recurrent yeast infections in autoimmune syndrome pinpointed. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2010/04/100410140439.htm
Rockefeller University. "Source of recurrent yeast infections in autoimmune syndrome pinpointed." ScienceDaily. www.sciencedaily.com/releases/2010/04/100410140439.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins