Featured Research

from universities, journals, and other organizations

Towards treating female sexual dysfunction: Research reveals secrets of female sexual arousal

Date:
April 13, 2010
Source:
Wiley-Blackwell
Summary:
By using a novel prototype drug, researchers have discovered more about the mechanisms underlying female sexual arousal.

By using a novel prototype drug, researchers have discovered more about the mechanisms underlying female sexual arousal.

These findings are published in the British Journal of Pharmacology.

A team of researchers based at Pfizer's labs in Sandwich, Kent, found that electrically stimulating the pelvic nerve increases blood flow to the genitalia, and that this effect was enhanced if they also gave a prototype drug (UK-414,495). They believe that the drug acts by blocking the breakdown of an internal chemical messenger that plays a key role in increasing blood flow during sexual arousal.

When women become aroused, blood flow increases to the vagina, labia and clitoris. This causes the organs to swell, and the vagina to relax, as well as increasing vaginal lubrication and the sensitivity of the genitalia.

Female sexual arousal disorder (FSAD) affects up to 40% of women irrespective of age. These women find that their genital organs do not respond to sexual stimulation, they find arousal difficult and this causes them to become distressed.

"Before this work, we knew surprisingly little about the processes that control all of these changes," says the lead researcher in the project Chris Wayman. "Now we are beginning to establish the pathways involved in sexual arousal scientists may be able to find ways of helping women who would like to overcome FSAD."

This is early stage research involving experimental studies using an animal model of sexual arousal. In it researchers stimulated the pelvic nerve and measured changes in genital organs. They believed the genital arousal occurred because stimulation of the nerve triggered the release of vasoactive intestinal peptide (VIP), a well-known neurotransmitter. VIP has only a short-lived effect, because it is soon broken down by an enzyme called Neutral Endopeptidase (NEP). The researchers believe that their prototype drug increased the arousal because it blocked NEP's ability to break down VIP, therefore letting the VIP have a more powerful and prolonged effect increasing arousal.

The results look all the more exciting because, while the drug did increase the level of sexual arousal, it didn't affect arousal in the absence of stimulation or the rest of the body's cardiovascular system. This suggests that this sort of drug would have a good chance of being safe to use in women, and would only work when combined with sexual stimulation.

"While the particular chemical compound studied in this research did not prove appropriate for further development, the implications of the research could lead to the development of a product in future, although Pfizer has no current plans to develop medicines for FSAD," added Wayman.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Towards treating female sexual dysfunction: Research reveals secrets of female sexual arousal." ScienceDaily. ScienceDaily, 13 April 2010. <www.sciencedaily.com/releases/2010/04/100413202651.htm>.
Wiley-Blackwell. (2010, April 13). Towards treating female sexual dysfunction: Research reveals secrets of female sexual arousal. ScienceDaily. Retrieved August 31, 2014 from www.sciencedaily.com/releases/2010/04/100413202651.htm
Wiley-Blackwell. "Towards treating female sexual dysfunction: Research reveals secrets of female sexual arousal." ScienceDaily. www.sciencedaily.com/releases/2010/04/100413202651.htm (accessed August 31, 2014).

Share This




More Mind & Brain News

Sunday, August 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com
Electrical Stimulation Boosts Brain Function, Study Says

Electrical Stimulation Boosts Brain Function, Study Says

Newsy (Aug. 29, 2014) Researchers found an improvement in memory and learning function in subjects who received electric pulses to their brains. Video provided by Newsy
Powered by NewsLook.com
Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins