Featured Research

from universities, journals, and other organizations

Discovery could help diabetics and others with slow-to-heal wounds

Date:
April 17, 2010
Source:
Loyola University Health System
Summary:
A discovery about the wound-healing process could lead to better treatments for diabetics and other patients who have wounds that are slow to heal.

A new discovery about the wound-healing process could lead to better treatments for diabetics and other patients who have wounds that are slow to heal.

Related Articles


Loyola University Health System researchers found that certain immune system cells slow the wound-healing process. Thus, it might be possible to improve healing by inactivating these immune system cells, said Elizabeth Kovacs, PhD, who heads the laboratory team that made the discovery.

The findings by Kovacs and colleagues are reported online, in advance of print, in the Journal of Surgical Research.

In the study, the immune system cells that impeded the healing process are called natural killer T (NKT) cells. NKT cells perform beneficial functions such as killing tumor cells and virus-infected cells. However, researchers discovered that NKT cells also migrate to wound sites and impede the healing process.

Kovacs and colleagues used an animal model to examine the effects of NKT cells on healing. Healing was significantly slower in normal mice that had NKT cells than it was in a special breed of mice that lacked NKT cells.

"We demonstrated that early wound closure was accelerated in the absence of NKT cells," Kovacs and colleagues wrote. "Importantly, we also made the novel observation that NKT cells themselves are a constituent of the early wound inflammatory infiltrate."

Certain conditions, such as diabetes and infections, can slow or prevent wounds from healing. The study found that NKT cells may be at least partially to blame. Researchers don't know how NKT cells slow healing. But they believe they may be able to inactivate NKT cells using an antibody. They are testing this prediction in a follow-up study.

Kovacs is a professor and vice chair of research in the Department of Surgery at Loyola University Chicago Stritch School of Medicine. She also is director of research of Loyola's Burn & Shock Trauma Institute.

Co-authors of the study are Jessica Palmer, Julia Tulley, Dr. John Speicher, Douglas Faunce, PhD, first author Dr. David Schneider and Dr. Richard Gamelli. Schneider is a resident at Loyola and Gamelli is dean of the Stritch School of Medicine and director of the Burn & Shock Trauma Institute.

The study was supported by the National Institutes of Health (NIH) and by the Ralph and Marion C. Falk Medical Research Trust.

Scott Somers, Ph.D., who manages wound healing research and training grants supported by the NIH's National Institute of General Medical Sciences, said, "Beyond the novel finding of a fundamental mechanism controlling wound healing, this work also highlights the contributions of physician-scientists like Dr. Schneider, a surgical resident who is training to do hypothesis-based, cutting-edge scientific investigation."


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. David F. Schneider, Jessica L. Palmer, Julia M. Tulley, Elizabeth J. Kovacs, Richard L. Gamelli, Douglas E. Faunce. Prevention of NKT Cell Activation Accelerates Cutaneous Wound Closure and Alters Local Inflammatory Signals. Journal of Surgical Research, 2010; DOI: 10.1016/j.jss.2010.03.030

Cite This Page:

Loyola University Health System. "Discovery could help diabetics and others with slow-to-heal wounds." ScienceDaily. ScienceDaily, 17 April 2010. <www.sciencedaily.com/releases/2010/04/100416185148.htm>.
Loyola University Health System. (2010, April 17). Discovery could help diabetics and others with slow-to-heal wounds. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2010/04/100416185148.htm
Loyola University Health System. "Discovery could help diabetics and others with slow-to-heal wounds." ScienceDaily. www.sciencedaily.com/releases/2010/04/100416185148.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins