Featured Research

from universities, journals, and other organizations

Excessive alcohol consumption may lead to increased cancer risk

Date:
April 21, 2010
Source:
American Association for Cancer Research
Summary:
Researchers have detected a link between alcohol consumption, cancer and aging that starts at the cellular level with telomere shortening.

Researchers have detected a link between alcohol consumption, cancer and aging that starts at the cellular level with telomere shortening.

Related Articles


Results of this cross-sectional study were presented at the American Association for Cancer Research 101st Annual Meeting 2010, held here, April 17-21, at the Walter E. Washington Convention Center.

Telomeres are found at the region of DNA sequences at the end of a chromosome, and are important for the genetic stability of cells. As people age, telomere length shortens progressively.

Excessive use of alcohol has been linked to oxidative stress and inflammation, two mechanisms that accelerate telomere shortening. Since telomere shortening is thought to increase cancer risk, the researchers speculated that those with shorter telomeres due to heavy alcohol consumption would have an increased risk of cancer.

"Heavy alcohol users tend to look haggard, and it is commonly thought heavy drinking leads to premature aging and earlier onset of diseases of aging. In particular, heavy alcohol drinking has been associated with cancer at multiple sites," said lead researcher Andrea Baccarelli, M.D., Ph.D.

"All the cells in our body have a biological clock in telomeres," noted Baccarelli, who is head of the Center of Molecular and Genetic Epidemiology, Ca' Granda Hospital Foundation, University of Milan, Italy.

Using real-time polymerase chain reaction, the researchers measured serum DNA among 59 participants who abused alcohol (22 percent consumed four or more alcoholic drinks per day) and 197 participants with variable alcohol consumption habits (4 percent consumed four or more alcoholic drinks per day).

The two groups were similar in age and other factors that might affect telomere length, such as diet, physical exercise, work-related stress and environmental exposures.

Results showed that telomere length was dramatically shortened in those who consumed heavy amounts of alcohol; telomere length was nearly half as long as telomere length in the non-abusers (0.41 vs. 0.79 relative units).

Carriers of the variant genotype ADH1B were more likely to be abusers and had shorter telomere length, according to Baccarelli.

"The decrease we found in telomere length is very sharp, and we were surprised to find such a strong effect at the cellular level," Baccarelli said.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Excessive alcohol consumption may lead to increased cancer risk." ScienceDaily. ScienceDaily, 21 April 2010. <www.sciencedaily.com/releases/2010/04/100421102336.htm>.
American Association for Cancer Research. (2010, April 21). Excessive alcohol consumption may lead to increased cancer risk. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2010/04/100421102336.htm
American Association for Cancer Research. "Excessive alcohol consumption may lead to increased cancer risk." ScienceDaily. www.sciencedaily.com/releases/2010/04/100421102336.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Ways To Celebrate National Nutrition Month

The Best Ways To Celebrate National Nutrition Month

Buzz60 (Mar. 2, 2015) Just when your New Year&apos;s Resolution is losing steam, March comes with fresh inspiration. TC Newman (@PurpleTCNewman) has some tips to incorporate into your lifestyle during National Nutrition Month. Video provided by Buzz60
Powered by NewsLook.com
WHO: 1.1 Billion At Risk Of Hearing Loss, Will They Listen?

WHO: 1.1 Billion At Risk Of Hearing Loss, Will They Listen?

Newsy (Mar. 2, 2015) According to the World Health Organization, 1.1 billion young people are at risk of hearing loss. Can this staggering number change things? Video provided by Newsy
Powered by NewsLook.com
Rehab Robot Helps Restore Damaged Muscles and Nerves

Rehab Robot Helps Restore Damaged Muscles and Nerves

Reuters - Innovations Video Online (Mar. 1, 2015) A rehabilitation robot prototype to help restore deteriorated nerves and muscles using electromyography and computer games. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins