Featured Research

from universities, journals, and other organizations

High blood cortisol levels significantly increases death rate in patients with acute coronary syndrome

Date:
May 27, 2010
Source:
European Society of Endocrinology
Summary:
Growing evidence suggests that serum cortisol levels are associated with increased cardiovascular mortality in patients with chronic heart failure.

Growing evidence suggests that serum cortisol levels are associated with increased cardiovascular mortality in patients with chronic heart failure, research presented at this week's European Congress of Endocrinology shows.

Until now, the significance of cortisol levels in patients with acute coronary syndrome (ACS) has been unknown. Cortisol is a hormone produced by the adrenal gland. Amongst other actions, it modifies our reactions to stress and anxiety, regulates blood pressure and helps to keep blood sugar levels within normal ranges. Now a group of researchers headed by Dr Andreas Tomaschitz at the Medical University of Graz-Austria (Team: Stefan Pilz, Medical University of Graz, Austria and Tanja Grammer, Synlab Center of Laboratory Diagnostics, Germany) have used the information from a German heart study to show the link between serum cortisol levels and increased mortality in patients with ACS.

The LURIC (Ludwigshafen Risk and Cardiovascular Health; headed by the principal investigator Prof. Winfried März, Synlab Center of Laboratory Diagnostics, Germany) study is an ongoing trial designed to investigate the effects of genetic and other biological traits on the cardiovascular system. The study has enrolled over 3000 participants for coronary angiography at the Herzzentrum, Ludwigshafen, Germany.

For this work, 1036 patients with acute coronary syndrome were studied for an average period of 7.7 years. There were no significant differences in the serum cortisol levels between patients with and without acute coronary syndrome. However, the patients with ACS and high cortisol levels had a significantly elevated number of deaths when compared to the patients with ACS and the lowest cortisol levels. 758 total deaths were reported during the follow-up period. The ACS patients with the highest cortisol levels (i.e. the highest 25% serum cortisol) were significantly more likely to die from fatal cardiovascular events than those with the lowest cortisol levels (the lowest 25% serum cortisol). (The hazard ratio for highest versus lowest quartile of SCC was 1.89 (1.12-3.19; P=0.018)).

Lead researcher, Dr Andreas Tomaschitz, said:

"These findings show for the first time that serum cortisol levels are strongly linked to higher death rates in patients with acute coronary syndrome. They suggest that cortisol might play an important role in worsening cardiovascular damage. Until now cortisol has been thought of as a non-specific stress indicator, but given that there was no real difference between the acute coronary syndrome and non acute coronary syndrome groups, we may have to reconsider this. In the future we will need to understand the complex way in which cells to react to cortisol, and how this causes cardiovascular damage to people with acute coronary syndrome."


Story Source:

The above story is based on materials provided by European Society of Endocrinology. Note: Materials may be edited for content and length.


Cite This Page:

European Society of Endocrinology. "High blood cortisol levels significantly increases death rate in patients with acute coronary syndrome." ScienceDaily. ScienceDaily, 27 May 2010. <www.sciencedaily.com/releases/2010/04/100426081316.htm>.
European Society of Endocrinology. (2010, May 27). High blood cortisol levels significantly increases death rate in patients with acute coronary syndrome. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2010/04/100426081316.htm
European Society of Endocrinology. "High blood cortisol levels significantly increases death rate in patients with acute coronary syndrome." ScienceDaily. www.sciencedaily.com/releases/2010/04/100426081316.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) — Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) — A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) — Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins