Featured Research

from universities, journals, and other organizations

More than half of liver patients experience neurocognitive impairments

Date:
May 8, 2010
Source:
Loyola University Health System
Summary:
Fifty-four percent of liver patients also display neurocognitive impairments such as short term memory loss, a study found. The average score of impaired patients was lower than that of patients with early-stage Alzheimer's disease.

More than half of patients who have cirrhosis of the liver also display neurocognitive impairments such as short term memory loss, a study led by a Loyola University Health System researcher has found.

Loyola neuropsychologist Christopher Randolph, PhD, and colleagues found that 54 percent of 301 cirrhosis patients who were tested scored below the 10th percentile for their age and education on a test that measures neurocognitive abilities.

"Neurocognitive impairment is a major issue in patients with liver disease," Randolph said. "This can affect patients' ability to do everyday tasks such as working, driving or managing their finances."

Randolph reported results May 3 during the Digestive Disease Week meeting of physicians and researchers in New Orleans. Randolph is a clinical professor in the Department of Neurology at Loyola University Chicago Stritch School of Medicine.

Neurocognitive impairment in liver patients is called hepatic encephalopathy. It is believed to be caused by toxins such as ammonia that diseased livers do not clear from the body. Randolph's study is the first to document how liver patients compare with the general population.

Liver patients from multiple centers nationwide were given a test developed by Randolph called the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS™). The widely used paper-and-pencil test takes 20 to 25 minutes and measures memory, attention, language and visual-spatial functions. It includes tasks such as identifying line drawings of common objects, repeating lists of digits, copying geometrical figures and recalling a story.

In the general population, the average score on RBANS tests is 100. Among liver patients in Randolph's study who had neurocognitive impairments, the average score was 74. This is lower than the average score of patients with early-stage Alzheimer's disease.

Prevalence of neurocognitive impairment was independent of age, gender, educational level or severity of the underlying disease.

The findings are a subset of a larger study to determine whether an experimental compound called AST-120 benefits liver patients who have neurocognitive impairments. AST-120 absorbs ammonia and other toxins. Patients have been randomly assigned to receive AST-120 or a placebo.

The study is funded by Ocera Therapeutics, which is developing compounds to treat liver diseases and other gastrointestinal disorders.


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Cite This Page:

Loyola University Health System. "More than half of liver patients experience neurocognitive impairments." ScienceDaily. ScienceDaily, 8 May 2010. <www.sciencedaily.com/releases/2010/05/100506121801.htm>.
Loyola University Health System. (2010, May 8). More than half of liver patients experience neurocognitive impairments. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2010/05/100506121801.htm
Loyola University Health System. "More than half of liver patients experience neurocognitive impairments." ScienceDaily. www.sciencedaily.com/releases/2010/05/100506121801.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins