Featured Research

from universities, journals, and other organizations

New method for developing safer drugs

Date:
May 10, 2010
Source:
University of Gothenburg
Summary:
Amodiaquine was introduced as an antimalarial drug, but was withdrawn when serious adverse effects were observed. Scientists in Sweden have now developed a method that can be used to develop safer drugs.

Amodiaquine was introduced as an antimalarial drug, but was withdrawn when serious adverse effects were observed. Scientists at the University of Gothenburg, Sweden, have now developed a method that can be used to develop safer drugs.

A pharmaceutical in the body is, in the optimal case, broken down into harmless products (metabolites) that leave the body, for example via the urine. Some pharmaceuticals, however, can be converted into toxic products, which may result in serious adverse effects. A research collaboration between the University of Gothenburg and AstraZeneca has resulted in a method that can facilitate the process of developing safe drugs.

Scientist Tove Johansson Mali'n presents in her thesis a method in which various chemical systems are used to simulate the metabolism of pharmaceuticals in the body. She has been able to use the method to identify and characterise several potentially toxic products that arise as the metabolites of drugs.

One example is the drug amodiaquine. This was introduced as an antimalarial drug, but was withdrawn from the market when it became clear that the drug caused serious adverse effects in the form of liver damage and impaired immune system. Amodiaquine today is mainly used in the acute phase of malaria, mainly in Africa, where resistance to other antimalarial drugs is widespread. Tove Johansson Mali'n has now managed to identify, with the aid of the method, previously unknown metabolites that may have caused, or contributed to, the adverse effects of amodiaquine.

Tove Johansson Mali'n describes the results in her doctoral thesis. The work has been performed in collaboration with the pharmaceuticals company AstraZeneca and is already attracting international attention. Tove Johansson Mali'n has been invited to Salt Lake City, USA at the end of May in order to present her results at an international conference arranged by the American Society for Mass Spectrometry, with 7,000 participants.

"We hope that the method can simplify the work of identifying potentially toxic metabolites at an early stage, and thus facilitate the development of safe drugs," says Tove Johansson Mali'n.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tove Johansson Mali'n, Lars Weidolf, Neal Castagnoli, Ulrik Jurva. P450-catalyzed vs. electrochemical oxidation of haloperidol studied by ultra-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2010; 24 (9): 1231 DOI: 10.1002/rcm.4505

Cite This Page:

University of Gothenburg. "New method for developing safer drugs." ScienceDaily. ScienceDaily, 10 May 2010. <www.sciencedaily.com/releases/2010/05/100509202645.htm>.
University of Gothenburg. (2010, May 10). New method for developing safer drugs. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2010/05/100509202645.htm
University of Gothenburg. "New method for developing safer drugs." ScienceDaily. www.sciencedaily.com/releases/2010/05/100509202645.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins