Featured Research

from universities, journals, and other organizations

Directing immune traffic: Signposts to the lung

Date:
May 12, 2010
Source:
Trudeau Institute
Summary:
Inducing cellular immunity as a means to protect against influenza virus is the focus of researchers who have recently identified two important signaling components required by the immune system that might allow us to pre-position our own virus-fighting T cells to the lungs, the site of initial infection.

Inducing cellular immunity as a means to protect against influenza virus is the focus of several laboratories at the Trudeau Institute. Researchers here have recently identified two important signaling components required by the immune system that might allow us to pre-position our own virus-fighting T cells to the lungs, the site of initial infection.

In laboratories around the world, researchers are working diligently to gain the upper hand in the ongoing struggle against the influenza virus. In 2009, with the emergence of H1N1 as a global threat, the scientific community was reminded how destructive the virus can be and how quickly a threat of its type can be transported across oceans and vast landmasses.

Clearly a new strategy is required to protect against this elusive virus. Current methods, which involve guesswork to determine the most likely strain and then setting about to develop a yearly vaccine, are both antiquated and time-consuming.

"It has become apparent that protective cellular immunity to viruses like influenza requires white blood cells to be pre-positioned in the lungs, the site of initial infection," says David L. Woodland, project leader and president of the institute. This approach has led to efforts to develop vaccines that persuade cells to localize in the respiratory tract. "That, however, has turned out to be difficult, because we don't fully understand the signals that direct immune cell migration to distinct locations in the body," Dr. Woodland added.

Woodland and colleagues have begun to shed light on this important question. They report in the current issue of the Journal of Experimental Medicine that two distinct signals are required to instruct virus-fighting white blood cells, known as T cells, to migrate into the lungs.

The first T cell is residual antigen (needed to stimulate antibodies) that remains in the lymph nodes for weeks after the initial infection has been cleared. The second is an "imprinting event" that instructs the T cells to specifically seek a target organ (in the case of flu, the lung). This imprinting event directs the T cells to where the original infectious agent entered the body and, importantly, where the cells need to go to fight future infections.

This new information has major implications for future vaccine research and could lead to the development of vaccines designed to promote immunity to respiratory infections.

Researchers are hopeful that, with further study, it may be possible to protect the population by prepositioning flu-fighting T cells in the lungs so they are in place when the body needs them.


Story Source:

The above story is based on materials provided by Trudeau Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shiki Takamura, Alan D. Roberts, Dawn M. Jelley-Gibbs, Susan T. Wittmer, Jacob E. Kohlmeier, David L. Woodland. The route of priming influences the ability of respiratory virus-specific memory CD8 T cells to be activated by residual antigen. Journal of Experimental Medicine, 2010; DOI: 10.1084/jem.20090283

Cite This Page:

Trudeau Institute. "Directing immune traffic: Signposts to the lung." ScienceDaily. ScienceDaily, 12 May 2010. <www.sciencedaily.com/releases/2010/05/100510121223.htm>.
Trudeau Institute. (2010, May 12). Directing immune traffic: Signposts to the lung. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2010/05/100510121223.htm
Trudeau Institute. "Directing immune traffic: Signposts to the lung." ScienceDaily. www.sciencedaily.com/releases/2010/05/100510121223.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins