Featured Research

from universities, journals, and other organizations

Intestinal damage after surgery

Date:
May 10, 2010
Source:
American Journal of Pathology
Summary:
In a new study, researchers in the Netherlands demonstrate that intestinal ischemia/reperfusion (I/R) induces inflammation in humans.

Dr. Joep Grootjans and colleagues at the Maastricht University Medical Center, Maastricht, the Netherlands demonstrate that intestinal ischemia/reperfusion (I/R) induces inflammation in humans. Their report can be found in the May 2010 issue of The American Journal of Pathology.

Intestinal I/R, the restriction and return of the blood supply to the intestine, is a common pathological side effect of surgery that leads to bacteria in the blood stream, systemic inflammation, and subsequent morbidity and mortality. Although intestinal I/R has been frequently studied in animal models, little is known about the inflammatory results of intestinal I/R in humans.

Using a human intestinal I/R model, Grootjans et al demonstrated that intestinal blood restriction in humans results in leakiness of the intestinal lining, which may allow bacteria to enter the blood stream. In addition, I/R-damaged intestinal tissue induced an inflammatory response. These data provide the basis for the development of future preventative and therapeutic strategies to treat I/R.

Dr. Gootjans and colleagues conclude that "[the] previously observed ability of the human small intestine to prevent intestinal I/R-induced inflammation is abolished by exposure to prolonged ischemia."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Grootjans J, Lenaerts K, Derikx JPM, Matthijsen RA, de Bruοne AP, van Bijnen AA, van Dam RM, Dejong CHC, Buurman WA. Human Intestinal Ischemia-Reperfusion-Induced Inflammation Characterized: Experiences from a New Translational Model. American Journal Of Pathology, 2010; 176 (5): 2283 DOI: 10.2353/ajpath.2010.091069

Cite This Page:

American Journal of Pathology. "Intestinal damage after surgery." ScienceDaily. ScienceDaily, 10 May 2010. <www.sciencedaily.com/releases/2010/05/100510141244.htm>.
American Journal of Pathology. (2010, May 10). Intestinal damage after surgery. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/05/100510141244.htm
American Journal of Pathology. "Intestinal damage after surgery." ScienceDaily. www.sciencedaily.com/releases/2010/05/100510141244.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) — Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) — Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Uganda on Alert for Ebola but No Confirmed Cases

Uganda on Alert for Ebola but No Confirmed Cases

AFP (July 31, 2014) — Uganda's health minister said on Thursday that there are no confirmed cases of Ebola in the country, but that it remained on alert for cases of the deadly virus. Uganda has suffered Ebola outbreaks in the past, most recently in 2012. Duration: 00:59 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins