Featured Research

from universities, journals, and other organizations

Intestinal damage after surgery

Date:
May 10, 2010
Source:
American Journal of Pathology
Summary:
In a new study, researchers in the Netherlands demonstrate that intestinal ischemia/reperfusion (I/R) induces inflammation in humans.

Dr. Joep Grootjans and colleagues at the Maastricht University Medical Center, Maastricht, the Netherlands demonstrate that intestinal ischemia/reperfusion (I/R) induces inflammation in humans. Their report can be found in the May 2010 issue of The American Journal of Pathology.

Intestinal I/R, the restriction and return of the blood supply to the intestine, is a common pathological side effect of surgery that leads to bacteria in the blood stream, systemic inflammation, and subsequent morbidity and mortality. Although intestinal I/R has been frequently studied in animal models, little is known about the inflammatory results of intestinal I/R in humans.

Using a human intestinal I/R model, Grootjans et al demonstrated that intestinal blood restriction in humans results in leakiness of the intestinal lining, which may allow bacteria to enter the blood stream. In addition, I/R-damaged intestinal tissue induced an inflammatory response. These data provide the basis for the development of future preventative and therapeutic strategies to treat I/R.

Dr. Gootjans and colleagues conclude that "[the] previously observed ability of the human small intestine to prevent intestinal I/R-induced inflammation is abolished by exposure to prolonged ischemia."

 


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Grootjans J, Lenaerts K, Derikx JPM, Matthijsen RA, de Bruοne AP, van Bijnen AA, van Dam RM, Dejong CHC, Buurman WA. Human Intestinal Ischemia-Reperfusion-Induced Inflammation Characterized: Experiences from a New Translational Model. American Journal Of Pathology, 2010; 176 (5): 2283 DOI: 10.2353/ajpath.2010.091069

Cite This Page:

American Journal of Pathology. "Intestinal damage after surgery." ScienceDaily. ScienceDaily, 10 May 2010. <www.sciencedaily.com/releases/2010/05/100510141244.htm>.
American Journal of Pathology. (2010, May 10). Intestinal damage after surgery. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2010/05/100510141244.htm
American Journal of Pathology. "Intestinal damage after surgery." ScienceDaily. www.sciencedaily.com/releases/2010/05/100510141244.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins