Featured Research

from universities, journals, and other organizations

Protein GRP78 opens the door to life-threatening fungal infection

Date:
May 17, 2010
Source:
Journal of Clinical Investigation
Summary:
Mucormycosis is a life-threatening fungal infection. It occurs predominantly in individuals with diabetes, in particular those with the potentially life-threatening complication known as diabetic ketoacidosis. New data, generated in mice, provide an explanation as to why patients with DKA are highly susceptible to mucormyosis and suggest a new avenue of research for those developing therapeutics for this life-threatening infection.

Mucormycosis is a life-threatening infection most commonly caused by a species of fungus known as Rhizopus oryzae. It occurs predominantly in individuals with diabetes, in particular those with the potentially life-threatening complication known as diabetic ketoacidosis.

A team of researchers, led by Ashraf Ibrahim, at the University of California Los Angeles, has now generated data in mice that provide an explanation as to why patients with DKA are highly susceptible to mucormyosis. The data also suggest a new avenue of research for those developing therapeutics for this life-threatening infection.

Mucormycosis is characterized by fungal invasion of the blood vessels, which results in blood clots forming in the blood vessels and local tissue destruction. In a series of in vitro experiments, the team identified the protein GRP78 as the protein to which Rhizopus oryzae binds on human blood vessel-lining cells. Interestingly, increased expression of GRP78 was observed on human blood vessel-lining cells cultured in levels of glucose and iron consistent with those seen during DKA and in the tissues that are affected during mucormycosis in mice with DKA, which are susceptible to the infection. Furthermore, mice with DKA were protected from murcomyosis by treatment with GRP78-specific immune serum.

These data provide an explanation as to why patients with DKA are highly susceptible to mucormycosis and have uncovered a potential new approach to treating this life-threatening infection.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mingfu Liu, Brad Spellberg, Quynh T. Phan, Yue Fu, Yong Fu, Amy S. Lee, John E. Edwards, Jr., Scott G. Filler, and Ashraf S. Ibrahim. The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI42164

Cite This Page:

Journal of Clinical Investigation. "Protein GRP78 opens the door to life-threatening fungal infection." ScienceDaily. ScienceDaily, 17 May 2010. <www.sciencedaily.com/releases/2010/05/100517171952.htm>.
Journal of Clinical Investigation. (2010, May 17). Protein GRP78 opens the door to life-threatening fungal infection. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2010/05/100517171952.htm
Journal of Clinical Investigation. "Protein GRP78 opens the door to life-threatening fungal infection." ScienceDaily. www.sciencedaily.com/releases/2010/05/100517171952.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins