Featured Research

from universities, journals, and other organizations

New study of psoriatic cells could fire up the study of inflammation

Date:
May 26, 2010
Source:
Rockefeller University
Summary:
New research promises to pry some long held secrets from one of humanity's oldest known diseases. Scientists have discovered how to parse the most troublesome cells behind the debilitating skin lesions in psoriasis and have identified several distinctive markers that suggest how they might be contributing to the disease -- a painful inflammation of the skin that afflicts up to 2 percent of the U.S. population.

Inflammatory images. New research homes in on molecules that define the most troublesome of two types of dendritic cells in psoriatic lesions. TRAIL (red) and CD11c (green) are thought to be key molecular contributors to the inflammatory activity of immature dendritic cells, which make up 80 percent to 90 percent of dendritic cells associated with psoriasis.
Credit: Image courtesy of Rockefeller University

New research promises to pry some long held secrets from one of humanity's oldest known diseases. Scientists at Rockefeller University have discovered how to parse the most troublesome cells behind the debilitating skin lesions in psoriasis and have identified several distinctive markers that suggest how they might be contributing to the disease -- a painful inflammation of the skin that afflicts up to 2 percent of the U.S. population.

Related Articles


The work, published online May 14 in the Journal of Allergy and Clinical Immunology, focused on special immune cells called dendritic cells, which are believed to be fundamental contributors to the disease. Two main types of dendritic cells are found in the lesions -- immature dendritic cells, which make up 80 percent to 90 percent of the population, and tissue-resident dendritic cells. Using cell sorting to separate the two types and then gene array analysis to identify the different molecules produced by each kind, researchers found that the immature dendritic cells expressed a host of genes that differentiated them from the resident dendritic cells.

Among them were molecules known as TNF-related apoptosis inducing ligand (TRAIL), Toll-Like Receptor (TLR) 1 and 2, and others that could fuel inflammatory pathways, says Michelle Lowes, assistant professor of clinical investigation in the Laboratory of Investigative Dermatology at Rockefeller's Center for Clinical and Translational Science. Knowing what molecules are active in psoriasis is key to understanding the disease, providing researchers a starting point for looking at genes that might contribute to it, and treatments that might prevent it.

"Different types of dendritic cells are really difficult to tease out," says Lowes, who worked with biomedical fellow Lisa Zaba and others on the project. "We wanted to publish this list of markers so that other people can look for any of their genes of interest."

Psoriasis is one of the most common inflammatory diseases and relatively easy to study because samples can be obtained from the skin. Despite its long-known and widespread prevalence, it is not well understood. A deeper knowledge of the inflammatory molecules at work in psoriasis could help develop treatments not only for the skin disorder but also for diseases ranging from allergies to arthritis and cancer.


Story Source:

The above story is based on materials provided by Rockefeller University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zaba et al. Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis. The Journal of Allergy and Clinical Immunology, 2010; DOI: 10.1016/j.jaci.2010.03.018

Cite This Page:

Rockefeller University. "New study of psoriatic cells could fire up the study of inflammation." ScienceDaily. ScienceDaily, 26 May 2010. <www.sciencedaily.com/releases/2010/05/100524104230.htm>.
Rockefeller University. (2010, May 26). New study of psoriatic cells could fire up the study of inflammation. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2010/05/100524104230.htm
Rockefeller University. "New study of psoriatic cells could fire up the study of inflammation." ScienceDaily. www.sciencedaily.com/releases/2010/05/100524104230.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins