Featured Research

from universities, journals, and other organizations

Vaccine hope for skin cancer sufferers

Date:
May 27, 2010
Source:
University of Nottingham
Summary:
Scientists have been given the green light to test a vaccine which they hope could reverse, and even cure malignant melanoma, the most deadly type of skin cancer.

Nottingham scientists have been given the green light to test a vaccine which they hope could reverse, and even cure malignant melanoma, the most deadly type of skin cancer.

Scancell Holdings plc, led by Professor Lindy Durrant of the University's Division of Clinical Oncology within the School of Molecular Medical Sciences, believes the new vaccine, which targets tumour cells without damaging healthy tissue, could be successful in treating patients with malignant melanoma.

Incidences of malignant melanoma have more than quadrupled over the past 30 years and in the last 25 years rates of malignant melanoma have risen faster than for any other cancer. It is now the most common cancer in younger adults aged 15 to 34, which may be linked to risky associated behaviour such as exposure to the sun on foreign beach holidays and the use of tanning booths. Every year, most of the 2,000 skin cancer deaths result from malignant melanoma.

Professor Durrant said: "Up until now, early diagnosis has been a crucial factor in the successful treatment of this disease. In the early stages it can be cured by completely removing the skin melanoma by surgery. However, in cases where it has not been picked up until further down the line, we have found that chemotherapy and radiotherapy simply do not work, although new compounds are being tested.

"It is still at a very early stage and impossible to predict the outcome of the clinical trial but if our results from the lab are replicated in patients I think we have a good chance of dramatically improving the chances of successful treatment -- we are hoping that the vaccine will cure between 10 and 20 per cent of patients with malignant melanoma."

Testing for the new SCIB1 vaccine has been given approval by the Gene Therapy Advisory Committee and the Medicines and Healthcare products Regulatory Agency and clinical trials are due to start shortly at Nottingham City Hospital and centres in Manchester and Newcastle.

It will initially be given to patients who are suffering from advanced malignant melanoma which has spread to other parts of the body.

The new vaccine works by activating the body's own natural defence systems -- it contains DNA and genetic material from tumours meaning it 'switches' on the specific immune cells that target melanoma. This means that it targets only the cancer and not the surrounding healthy tissue.

The team of scientists believe that, in principle, new vaccines based upon the same principle could also be used to target other types of cancer tumours, such as breast and prostate.


Story Source:

The above story is based on materials provided by University of Nottingham. Note: Materials may be edited for content and length.


Cite This Page:

University of Nottingham. "Vaccine hope for skin cancer sufferers." ScienceDaily. ScienceDaily, 27 May 2010. <www.sciencedaily.com/releases/2010/05/100526095814.htm>.
University of Nottingham. (2010, May 27). Vaccine hope for skin cancer sufferers. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2010/05/100526095814.htm
University of Nottingham. "Vaccine hope for skin cancer sufferers." ScienceDaily. www.sciencedaily.com/releases/2010/05/100526095814.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins