Featured Research

from universities, journals, and other organizations

How reliable is prognostic research? A case study of C-reactive protein in coronary artery disease

Date:
June 1, 2010
Source:
Public Library of Science
Summary:
Prognostic markers provide tools for discriminating between groups of patients who are at different risks of a particular outcome, and therefore should help clinicians to manage disease.

Prognostic markers provide tools for discriminating between groups of patients who are at different risks of a particular outcome, and therefore should help clinicians to manage disease. In a comprehensive overview of studies looking at one such proposed marker, C-reactive protein (CRP) in coronary artery disease, Harry Hemingway and colleagues, from University College London, show that despite the inclusion of many tens of thousands of patients in research on this specific question, the published record is so inadequate that no clear clinical recommendations can be made.

Related Articles


In the study, published in PLoS Medicine, the authors carried out a detailed systematic review to identify all prospective studies reporting risk of a coronary, cardiovascular, or mortality outcome among patients in whom the CRP values had been measured. They identified 83 studies in the published scientific literature, in which data was reported for 61,684 patients, and 6,485 outcomes. A straightforward analysis of the results of these studies suggested overall evidence for a fairly strong increase in risk associated with higher CRP levels. However, the authors found strong evidence of publication bias. This occurred owing to non-publication of studies with contradictory findings to those which did get published. In an attempt to adjust for publication bias, the researchers estimated that CRP would have a much smaller strength of association with coronary or death outcomes. Finally, the authors also identified a low standard of repor ting quality for many of the published studies, and multiple types of reporting bias in the literature.

Given these biases, the authors conclude that the data "preclude firm conclusions about the magnitude and independence of the association between higher CRP levels and higher risk of subsequent death and nonfatal cardiovascular events." They propose that improvements are needed in the design and reporting of this type of research. Critically, in reporting of these studies it is unclear whether analyses are being included in a publication because the direction of the result suggests something interesting, or because the original study plan specified it; a proposal included in the paper is that study protocols for prognostic research should be registered in advance.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hemingway et al. Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease. PLoS Medicine, 2010; 7 (6): e1000286 DOI: 10.1371/journal.pmed.1000286

Cite This Page:

Public Library of Science. "How reliable is prognostic research? A case study of C-reactive protein in coronary artery disease." ScienceDaily. ScienceDaily, 1 June 2010. <www.sciencedaily.com/releases/2010/06/100601171713.htm>.
Public Library of Science. (2010, June 1). How reliable is prognostic research? A case study of C-reactive protein in coronary artery disease. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/06/100601171713.htm
Public Library of Science. "How reliable is prognostic research? A case study of C-reactive protein in coronary artery disease." ScienceDaily. www.sciencedaily.com/releases/2010/06/100601171713.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins