Featured Research

from universities, journals, and other organizations

Lovastatin: a new weapon against plague?

Date:
June 4, 2010
Source:
CNRS (Délégation Paris Michel-Ange)
Summary:
An experimental study has revealed that lovastatin, a drug prescribed for the treatment of hypercholesterolemia, protects animals against the deadly effects of plague. This infectious disease is on the upsurge in parts of the world. These results obtained by scientists at the Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (CNRS/Université Aix-Marseille 2) have been published in the journal PLoS ONE.

Colonies of Yersinia pestis after culture on CIN agar.
Credit: Copyright URMITE / CNRS

An experimental study has revealed that lovastatin, a drug prescribed for the treatment of hypercholesterolemia, protects animals against the deadly effects of plague. This infectious disease is on the upsurge in parts of the world. These results obtained by scientists at the Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (CNRS/Université Aix-Marseille 2) have been published in the journal PLoS One.

Related Articles


Statins are a class of medicinal products administered to reduce cholesterol levels in people at risk of suffering heart disease because of their hypercholesterolemia. Of the six statin compounds available, lovastatin was the first to be introduced onto the market. Although studies have already demonstrated that this drug can prevent the mortality and morbidity associated with severe infections, no results concerning the bacterium that causes fatal plague, called Yersinia pestis, had been available until now.

After inoculating small rodents with the Yersinia pestis bacterium, the team led by Didier Raoult and Michel Drancourt at the URMITE (CNRS/Université Aix-Marseille 2) showed that animals treated with lovastatin presented fewer and less severe infections. Lovastatin therefore has preventive properties against plague mortality in an animal model. This experimental study also reveals that this statin has no direct antibiotic effect against Yersinia pestis but that it prevents the development of septicemia.

These findings suggest that people receiving statin-based treatment to reduce their cholesterol levels may be protected against the deadly effects of plague. The cause of severe epidemics over the last two thousand years, plague is now considered as a resurgent disease throughout the world. Nearly 50% of cases worldwide are reported in Madagascar, but plague is present in Africa (Democratic Republic of Congo, Malawi and Tanzania), Asia (Vietnam) and America, while a few very limited outbreaks have been observed in Europe on the shores of the Caspian Sea.


Story Source:

The above story is based on materials provided by CNRS (Délégation Paris Michel-Ange). Note: Materials may be edited for content and length.


Journal Reference:

  1. Ayyadurai et al. Lovastatin Protects against Experimental Plague in Mice. PLoS ONE, 2010; 5 (6): e10928 DOI: 10.1371/journal.pone.0010928

Cite This Page:

CNRS (Délégation Paris Michel-Ange). "Lovastatin: a new weapon against plague?." ScienceDaily. ScienceDaily, 4 June 2010. <www.sciencedaily.com/releases/2010/06/100604073638.htm>.
CNRS (Délégation Paris Michel-Ange). (2010, June 4). Lovastatin: a new weapon against plague?. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2010/06/100604073638.htm
CNRS (Délégation Paris Michel-Ange). "Lovastatin: a new weapon against plague?." ScienceDaily. www.sciencedaily.com/releases/2010/06/100604073638.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Humanoid Robot Can Recognise and Interact With People

Humanoid Robot Can Recognise and Interact With People

Reuters - Innovations Video Online (Apr. 20, 2015) — An ultra-realistic humanoid robot called &apos;Han&apos; recognises and interprets people&apos;s facial expressions and can even hold simple conversations. Developers Hanson Robotics hope androids like Han could have uses in hospitality and health care industries where face-to-face communication is vital. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Labour Party Warns Britain's Health Service 'on Life Support'

Labour Party Warns Britain's Health Service 'on Life Support'

AFP (Apr. 20, 2015) — Britain&apos;s opposition Labour Party Monday claimed the National Health Service (NHS) was &apos;on life support&apos; as it turned its attention to the state-run service, which is a key issue for the UK&apos;s May 7 general election. Video provided by AFP
Powered by NewsLook.com
Sierra Leone Students Back to School After Long Ebola Closure

Sierra Leone Students Back to School After Long Ebola Closure

Reuters - News Video Online (Apr. 20, 2015) — After an eight-month break, children in Sierra Leone return to school for the first time since the beginning of the Ebola outbreak. Nathan Frandino reports. Video provided by Reuters
Powered by NewsLook.com
Teen E-Cigarette Use Triples, Government Debates Regulations

Teen E-Cigarette Use Triples, Government Debates Regulations

Newsy (Apr. 19, 2015) — The Centers for Disease Control and Prevention says in 2014, 13.4 percent of high school students reported smoking an e-cigarette within 30 days. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins