Featured Research

from universities, journals, and other organizations

'Remote control' for cholesterol regulation discovered in brain

Date:
June 7, 2010
Source:
University of Cincinnati Academic Health Center
Summary:
Circulation of cholesterol is regulated in the brain by the hunger-signaling hormone ghrelin, researchers say. The finding points to a new potential target for the pharmacologic control of cholesterol levels.

Circulation of cholesterol is regulated in the brain by the hunger-signaling hormone ghrelin, researchers say. The finding points to a new potential target for the pharmacologic control of cholesterol levels.

The animal study, led by Matthias Tschöp, MD, professor in the University of Cincinnati (UC) endocrinology division, appears online ahead of print June 6, 2010, in Nature Neuroscience.

"We have long thought that cholesterol is exclusively regulated through dietary absorption or synthesis and secretion by the liver," says Tschöp. "Our study shows for the first time that cholesterol is also under direct 'remote control' by specific neurocircuitry in the central nervous system."

The hormone ghrelin inhibits the melanocortin 4 receptor (MC4R) in the hypothalamus and is important for the regulation of food intake and energy expenditure. Tschöp and his team found that increased levels of ghrelin in mice caused the animals to develop increased levels of blood-circulating cholesterol. This, the authors say, is due to a reduction in the uptake of cholesterol by the liver.

The research team next tested the effects of genetically deleting or chemically blocking MC4R in the central nervous system. This test also yielded increased levels of cholesterol, suggesting that MC4R was the central element of the "remote control."

"We were stunned to see that by switching MC4R off in the brain, we could even make injected cholesterol remain in the blood much longer," says Tschöp, a researcher at UC's Metabolic Diseases Institute.

Cholesterol is a type of naturally occurring fat needed by the body, but too much cholesterol can lead to atherosclerosis, a buildup of plaque in the arteries. There are two types of cholesterol in humans―HDL (high-density lipoprotein) and LDL (low-density lipoprotein). LDL is considered the "bad" kind of cholesterol responsible for plaque buildup. HDL is the "good" kind that, in high levels, can prevent atherosclerosis.

Atherosclerosis can lead to heart attack. The American Heart Association estimates that a heart attack occurs every 34 seconds in the United States.

Due to the differences in the make-up of mice and human cholesterol, Tschöp and his team say more work is needed before their studies could be directly applied to humans, but they say their finding adds to a growing body of evidence for the central nervous system's direct control over essential metabolic processes.

This study was supported by a grant from the National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases.

Co-authors include Stephen Benoit, Joshua Bashford, William Davidson, Norm Granholm, Erin Grant, Susanna Hofmann, David Hui, Ruben Nogueiras, Diego Perez-Tilve, Paul Pfluger, Hilary Wilson-Perez and Stephen Woods, all from the University of Cincinnati; Myrtha Arnold from the Institute of Animal Science in Schwerzenbach, Switzerland; Andrew Butler and James Trevaskis from Pennington Biomedical Research Center in Louisiana; James Patterson and Mark Sleeman from Regeneron Pharmaceuticals; and Richard DiMarchi from Indiana University.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Diego Perez-Tilve, Susanna M Hofmann, Joshua Basford, Ruben Nogueiras, Paul T Pfluger, James T Patterson, Erin Grant, Hilary E Wilson-Perez, Norman A Granholm, Myrtha Arnold, James L Trevaskis, Andrew A Butler, William S Davidson, Stephen C Woods, Stephen C Benoit, Mark W Sleeman, Richard D DiMarchi, David Y Hui & Matthias H Tschöp. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nature Neuroscience, June 6, 2010 DOI: 10.1038/nn.2569

Cite This Page:

University of Cincinnati Academic Health Center. "'Remote control' for cholesterol regulation discovered in brain." ScienceDaily. ScienceDaily, 7 June 2010. <www.sciencedaily.com/releases/2010/06/100606162134.htm>.
University of Cincinnati Academic Health Center. (2010, June 7). 'Remote control' for cholesterol regulation discovered in brain. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2010/06/100606162134.htm
University of Cincinnati Academic Health Center. "'Remote control' for cholesterol regulation discovered in brain." ScienceDaily. www.sciencedaily.com/releases/2010/06/100606162134.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins