Featured Research

from universities, journals, and other organizations

Non-IV-administered medication just as effective in stopping seizures, expert says

Date:
June 7, 2010
Source:
University of Cincinnati Academic Health Center
Summary:
When seizures strike, the most immediate goal for caregivers is to get appropriate medication to the patient as quickly as possible to stop the seizing activity.

When seizures strike, the most immediate goal for caregivers is to get appropriate medication to the patient as quickly as possible to stop the seizing activity.

Related Articles


In a paper published in the June Academic Emergency Medicine, UC emergency medicine assistant professor Jason McMullan, MD, found that the best means of stopping status epilepticus (SE) may be with the least direct medication.

In the meta-analysis, McMullan compiled the results of six studies featuring 774 patients. His analysis compared the efficacy of two seizure medications, diazepam and non-intravenous midazolam, in stopping SE in children and young adults.

Both medications are in a class of drugs called benzodiapines, with diazepam the more commonly used anti-seizure drug in pre-hospital settings. While diazepam is typically administered by either suppository or IV, midazolam can be administered by a shot in the muscle or intranasally.

In the minutes after a seizure, the method of administration can make a big difference, says McMullan.

"Establishing IV access can be challenging, if not impossible, in convulsing patients," he says. While an intravenous medication may access the bloodstream faster, it can take a long time before the patient actually gets the medicine.

"Suppositories present another challenge," adds McMullan, because some caregivers may be unwilling to administer a suppository to a seizing child in a public place.

"It may be a little bit slower for midazolam administered via shot or nasal spray to work," he says, "but when you factor in the time to start the IV or administer a suppository, then it becomes a lot quicker."

During a seizure, time saved often translates into a better outcome for the patient.

"Most seizures stop on their own, but there times that they don't -- and when they don't, that's a true emergency," says McMullan. "If a person is seizing for five or more minutes, the chances of the seizure stopping on its own are far less. During that time the person can suffer brain damage, muscle damage, a lack of oxygen, kidney damage, any number of things. The sooner that person is treated, the better they're going to do and the less medicine that they need."

In the analysis, McMullan found that midazolam, administered by any route, was superior to diazepam for stopping seizures, by any route. Not only was midazolam administered faster that diazepam, it had no greater rate of respiratory side effects.

While McMullan cautions that further studies including adult patients and comparing other anti-seizure medications are needed, he is optimistic about what this means for advancing the standard of care in seizures.

"In broad strokes, these results mean midazolam could be a good idea for seizure treatment. It's no worse than the gold standard of putting the drug directly into the bloodstream, it's no more dangerous and it's quicker. The real promise if that it may open the possibility for more EMS agencies to use this medication."

Co-authors include UC emergency medicine professor Arthur Pancioli, MD, and University of Michigan emergency medicine associate professor Robert Silbergleit, MD, and lecturer Comilla Sasson, MD.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati Academic Health Center. "Non-IV-administered medication just as effective in stopping seizures, expert says." ScienceDaily. ScienceDaily, 7 June 2010. <www.sciencedaily.com/releases/2010/06/100607122442.htm>.
University of Cincinnati Academic Health Center. (2010, June 7). Non-IV-administered medication just as effective in stopping seizures, expert says. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2010/06/100607122442.htm
University of Cincinnati Academic Health Center. "Non-IV-administered medication just as effective in stopping seizures, expert says." ScienceDaily. www.sciencedaily.com/releases/2010/06/100607122442.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins