Featured Research

from universities, journals, and other organizations

'Scout scans' map the way in non-Hodgkin's lymphoma treatment

Date:
June 7, 2010
Source:
Society of Nuclear Medicine
Summary:
According to a new study, molecular imaging can evaluate and optimize non-Hodgkin's lymphoma therapy with Zevalin, a front-line radioimmunotherapy drug that uses a dose of radioactive material and mimics the body's own immune response to target and kill cancer cells while sparing nearby healthy tissues.

According to a study presented at the Society of Nuclear Medicine's 57th Annual Meeting, molecular imaging can evaluate and optimize non-Hodgkin's lymphoma therapy with Zevalin, a front-line radioimmunotherapy drug that uses a dose of radioactive material and mimics the body's own immune response to target and kill cancer cells while sparing nearby healthy tissues.

"By using molecular imaging prior to treatment, physicians can improve the targeting of radioimmunotherapy and even allow for a larger and considerably more powerful radiation dose to the cancer without damaging surrounding healthy organs," said Nafees Rizvi, M.D., department of nuclear medicine and PET research, VU University Medical Center, Amsterdam, The Netherlands. "This allows for an individualized approach to treatments, tailoring therapies to the individual patient."

Non-Hodgkin's lymphoma, a cancer of the lymphatic system, is considered the fifth-most common cancer in America. There are many different forms of lymphoma, and treatment is determined based on disease progression and the kinds of cells affected. Radioimmunotherapy is a relatively new and highly targeted combination of radiation and immunotherapy that uses molecular imaging to pinpoint the exact location of tumor cells. Once therapy has been mapped, physicians inject antibodies matched with a radioactive substance that heads straight for the antigens of cancer cells, much like how the body's natural immune system works against common viruses and infections. The antibodies bind to the cancer cells, delivering a deadly dose of radiation to the tumor.

This study was conducted to test the effectiveness of a molecular imaging agent called Zr-89-Zevalin, which is used in conjunction with positron emission tomography (PET), a molecular imaging technique that images biological process in the body. Zr-89-Zevalin was tested as the imaging agent for "scout scans" -- initial PET scans used for treatment planning prior to therapy -- for six patients with relapsed B-cell non-Hodgkin's lymphoma scheduled for stem-cell transplant. Participants received PET scans after an injection of the imaging agent and again after receiving radioimmunotherapy. The imaging agent provided an accurate portrait of the biodistribution, or the likely path in the body, of a therapeutic dose of Y-90-Zevalin, without any negative impact from simultaneous injection. Results indicate that Zr-89-Zevalin and PET could be more effective than other imaging techniques and could lead to more effective and personalized therapy with Y-90-Zevalin.

Scientific Paper 60: S. Rizvi, G.A. van Dongen, O.S. Hoekstra, M. Lubberink, Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, Netherlands; O. Visser, J. Zijlstra, P.C. Huijgens, Hematology, VU University Medical Center, Amsterdam, Netherlands; "Biodistribution and radiation dosimetry of Y-ibritumomab-tiuxetan using Zr-ibritumomab-tiuxetan and PET in patients with relapsed B-cell non-Hodgkin's lymphoma," SNM's 57th Annual Meeting, June 5-9, 2010, Salt Lake City, Utah.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "'Scout scans' map the way in non-Hodgkin's lymphoma treatment." ScienceDaily. ScienceDaily, 7 June 2010. <www.sciencedaily.com/releases/2010/06/100607142057.htm>.
Society of Nuclear Medicine. (2010, June 7). 'Scout scans' map the way in non-Hodgkin's lymphoma treatment. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/06/100607142057.htm
Society of Nuclear Medicine. "'Scout scans' map the way in non-Hodgkin's lymphoma treatment." ScienceDaily. www.sciencedaily.com/releases/2010/06/100607142057.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins