Featured Research

from universities, journals, and other organizations

How to overcome resistance to one group of breast cancer drugs

Date:
June 11, 2010
Source:
Journal of Clinical Investigation
Summary:
New research has identified a mechanism by which human breast cancer cells can develop resistance to one group of drugs used to treat breast cancer, suggesting new approaches to treating the disease.

A team of researchers, led by Carlos Arteaga, at Vanderbilt University Medical Center, Nashville, has identified a mechanism by which human breast cancer cells can develop resistance to one group of drugs used to treat breast cancer, suggesting new approaches to treating the disease.

A large proportion of breast cancers express the molecule to which the sex hormone estrogen binds and show a degree of dependence on the hormone for growth. Patients with such tumors are usually treated with drugs known as endocrine therapies that interfere with estrogen signaling to the tumor cell. However, some cancers develop resistance to endocrine therapies after initially responding.

To define mechanisms underlying the development of resistance to endocrine therapies, Arteaga and colleagues analyzed molecular changes in human breast cancer cell lines subject to long-term estrogen deprivation (a condition that mimics an endocrine therapy regimen). They found evidence of PI3K signaling pathway activation, and cells treated with a PI3K inhibitor died. As a breast tumor protein signature of PI3K pathway activation was found to predict poor outcome after endocrine therapy in patients, the authors suggest that combining an endocrine therapy with a PI3K pathway inhibitor might help prevent the development of resistance to endocrine therapies in patients with breast cancer.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Todd W. Miller, Bryan T. Hennessy, Ana M. González-Angulo, Emily M. Fox, Gordon B. Mills, Heidi Chen, Catherine Higham, Carlos García-Echeverría, Yu Shyr, and Carlos L. Arteaga. Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor%u2013positive human breast cancer. Journal of Clinical Investigation, June 7, 2010 DOI: 10.1172/JCI41680

Cite This Page:

Journal of Clinical Investigation. "How to overcome resistance to one group of breast cancer drugs." ScienceDaily. ScienceDaily, 11 June 2010. <www.sciencedaily.com/releases/2010/06/100607192716.htm>.
Journal of Clinical Investigation. (2010, June 11). How to overcome resistance to one group of breast cancer drugs. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2010/06/100607192716.htm
Journal of Clinical Investigation. "How to overcome resistance to one group of breast cancer drugs." ScienceDaily. www.sciencedaily.com/releases/2010/06/100607192716.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) — As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) — Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) — Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) — Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins