Featured Research

from universities, journals, and other organizations

Findings could help diagnose and treat liver cancer; Researchers identify an enzyme important for cancer’s ability to spread

Date:
June 8, 2010
Source:
Van Andel Research Institute
Summary:
In collaboration with the National Cancer Center, Singapore, Van Andel Research Institute (VARI) researchers have identified an enzyme that could help diagnose and treat cholangiocarcinoma, a form of liver cancer that strikes up to 3,000 new patients each year in the United States.

Liver cancer tissue.
Credit: Image courtesy of Van Andel Research Institute

In collaboration with the National Cancer Centre, Singapore, Van Andel Research Institute (VARI) researchers have identified an enzyme that could help diagnose and treat cholangiocarcinoma, a form of liver cancer that strikes up to 3,000 new patients each year in the United States.

Related Articles


Cholangiocarcinoma is the second most common type of cancer that affects the hepatobiliary system, which includes the liver, gall bladder, and bile ducts. The disease is most commonly diagnosed in patients in their 60's and 70's, and prognosis is generally poor with a 5-year survival rate of less than 5%. The only current curative treatment of the disease is surgery to remove all tumor tissue, but most patients' cancer is too advanced upon diagnosis to operate.

Southeast Asia is particularly affected by cholangiocarcinoma, but incidence of the disease is rising in the United States, United Kingdom, and Australia.

"An advance in the diagnosis and treatment of this disease could have a profound impact," said Professor Khee Chee Soo, Director of the National Cancer Centre, Singapore. "Cholangiocarcinoma is especially prevalent in Southeast Asia where, because of chronic infections by liver flukes and other factors, it kills thousands each year."

Cholangiocarcinoma and hepatocellularcarcinoma (HCC) are the two main forms of malignant liver cancer and require different treatments. Researchers found that the enzyme p38delta mitogen-activated protein kinase (MAPK13) is found in higher levels in cholangiocarcinomas than in HCC or normal tissue, and that it plays a role in the ability of tumor cells to move and invade normal tissue.

MAPK13 could be used as a complement to current biomarkers in diagnosing cholangiocarcinoma and distinguishing it from HCC, and it could serve as a drug target to help treat cholangiocarcinoma.

"Cholangiocarcinomas are notoriously challenging to diagnose and treat," said VARI Distinguished Scientific Investigator Bin Tean Teh, M.D., Ph.D., whose laboratory published its findings in the May 15 issue of the International Journal of Cancer. "Discoveries that lead to earlier detection and diagnosis will improve the long-term survival rate of patients."

Tissues used in the study were obtained from the National Cancer Centre, Singapore, and the Singapore General Hospital.

This work was partly supported by the Singapore Millennium Foundation and the National Cancer Centre Research Foundation.


Story Source:

The above story is based on materials provided by Van Andel Research Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Felicia Li-Sher Tan, Aikseng Ooi, Dachuan Huang, Jing Chii Wong, Chao-Nan Qian, Cora Chao, London Ooi, Yu-Meng Tan, Alexander Chung, Peng-Chung Cheow, Zhongfa Zhang, David Petillo, Ximing J. Yang, Bin Tean Teh. p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion. International Journal of Cancer, 2009; NA DOI: 10.1002/ijc.24944

Cite This Page:

Van Andel Research Institute. "Findings could help diagnose and treat liver cancer; Researchers identify an enzyme important for cancer’s ability to spread." ScienceDaily. ScienceDaily, 8 June 2010. <www.sciencedaily.com/releases/2010/06/100608183046.htm>.
Van Andel Research Institute. (2010, June 8). Findings could help diagnose and treat liver cancer; Researchers identify an enzyme important for cancer’s ability to spread. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2010/06/100608183046.htm
Van Andel Research Institute. "Findings could help diagnose and treat liver cancer; Researchers identify an enzyme important for cancer’s ability to spread." ScienceDaily. www.sciencedaily.com/releases/2010/06/100608183046.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Toddlers Drinking Coffee? Why You Shouldn't Share Your Joe

Newsy (Mar. 5, 2015) A survey of Boston mothers and toddlers found that 15 percent of two-year-olds drink coffee and 2.5 percent of 1-year-olds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins