Featured Research

from universities, journals, and other organizations

Prior exposure to seasonal influenza may explain the mildness of the 2009 H1N1 pandemic

Date:
June 21, 2010
Source:
American Society for Microbiology
Summary:
Researchers suggest a new theory for why swine flu infections turned out to be so mild. Prior exposure to seasonal influenza A, either infection or vaccination, may induce a cross-reactive immune response against the pandemic virus.

Hong Kong researchers suggest a new theory for why swine flu infections turned out to be so mild. Prior exposure to seasonal influenza A, either infection or vaccination, may induce a cross-reactive immune response against the pandemic virus. They report their findings in the July 2010 issue of the Journal of Virology.

Although the outbreak of human H1N1 in 2009 spread to pandemic proportions, the illness was considered mild in most patients compared to seasonal influenza. Currently available seasonal flu vaccines do not offer cross-reactivity to pandemic H1N1 in any age group, suggesting that individuals previously infected or exposed to seasonal influenza A viruses may have memory cell-induced cross-protection to pandemic H1N1.

Prior research showed humans having cross-reactive memory cells to a wide range of H5N1 peptides despite any previous exposure to avian influenza A (H5N1). In this study researchers determined that memory cells established by seasonal influenza viruses can break down pandemic H1N1-infected target cells and ultimately induce cross-protective antibodies.

"Our data suggest that individuals who were infected with seasonal human influenza A viruses previously or who received seasonal human influenza vaccines may derive benefit, at least in part, from the preexisting cross-reactive memory cytotoxic T lymphocytes to reduce the severity of pdmH1N1 infection even without protective antibodies," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. W. Tu, H. Mao, J. Zheng, Y. Liu, S.S. Chiu, G. Qin, P.L. Chan, K.T. Lam, J. Guan, L. Zhang, Y. Guan, K.Y. Yuen, J.S. Malik Peiris, Y.L. Lau. Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-React against 2009 Pandemic H1N1 Influenza Virus. Journal of Virology, 2010; 84 (13): 6527 DOI: 10.1128/JVI.00519-10

Cite This Page:

American Society for Microbiology. "Prior exposure to seasonal influenza may explain the mildness of the 2009 H1N1 pandemic." ScienceDaily. ScienceDaily, 21 June 2010. <www.sciencedaily.com/releases/2010/06/100618142332.htm>.
American Society for Microbiology. (2010, June 21). Prior exposure to seasonal influenza may explain the mildness of the 2009 H1N1 pandemic. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2010/06/100618142332.htm
American Society for Microbiology. "Prior exposure to seasonal influenza may explain the mildness of the 2009 H1N1 pandemic." ScienceDaily. www.sciencedaily.com/releases/2010/06/100618142332.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins