Featured Research

from universities, journals, and other organizations

Prior exposure to seasonal influenza may explain the mildness of the 2009 H1N1 pandemic

Date:
June 21, 2010
Source:
American Society for Microbiology
Summary:
Researchers suggest a new theory for why swine flu infections turned out to be so mild. Prior exposure to seasonal influenza A, either infection or vaccination, may induce a cross-reactive immune response against the pandemic virus.

Hong Kong researchers suggest a new theory for why swine flu infections turned out to be so mild. Prior exposure to seasonal influenza A, either infection or vaccination, may induce a cross-reactive immune response against the pandemic virus. They report their findings in the July 2010 issue of the Journal of Virology.

Related Articles


Although the outbreak of human H1N1 in 2009 spread to pandemic proportions, the illness was considered mild in most patients compared to seasonal influenza. Currently available seasonal flu vaccines do not offer cross-reactivity to pandemic H1N1 in any age group, suggesting that individuals previously infected or exposed to seasonal influenza A viruses may have memory cell-induced cross-protection to pandemic H1N1.

Prior research showed humans having cross-reactive memory cells to a wide range of H5N1 peptides despite any previous exposure to avian influenza A (H5N1). In this study researchers determined that memory cells established by seasonal influenza viruses can break down pandemic H1N1-infected target cells and ultimately induce cross-protective antibodies.

"Our data suggest that individuals who were infected with seasonal human influenza A viruses previously or who received seasonal human influenza vaccines may derive benefit, at least in part, from the preexisting cross-reactive memory cytotoxic T lymphocytes to reduce the severity of pdmH1N1 infection even without protective antibodies," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. W. Tu, H. Mao, J. Zheng, Y. Liu, S.S. Chiu, G. Qin, P.L. Chan, K.T. Lam, J. Guan, L. Zhang, Y. Guan, K.Y. Yuen, J.S. Malik Peiris, Y.L. Lau. Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-React against 2009 Pandemic H1N1 Influenza Virus. Journal of Virology, 2010; 84 (13): 6527 DOI: 10.1128/JVI.00519-10

Cite This Page:

American Society for Microbiology. "Prior exposure to seasonal influenza may explain the mildness of the 2009 H1N1 pandemic." ScienceDaily. ScienceDaily, 21 June 2010. <www.sciencedaily.com/releases/2010/06/100618142332.htm>.
American Society for Microbiology. (2010, June 21). Prior exposure to seasonal influenza may explain the mildness of the 2009 H1N1 pandemic. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2010/06/100618142332.htm
American Society for Microbiology. "Prior exposure to seasonal influenza may explain the mildness of the 2009 H1N1 pandemic." ScienceDaily. www.sciencedaily.com/releases/2010/06/100618142332.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins