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Immune Cells and Atherosclerosis

Date:
June 25, 2010
Source:
American Journal of Pathology
Summary:
Researchers demonstrate that neutrophils may contribute to atherosclerosis.

Dr. Einar Eriksson and colleagues at the Karolinska Hosptial, Stockholm, Sweden demonstrate that neutrophils may contribute to atherosclerosis. Their report can be found in the July 2010 issue of The American Journal of Pathology.

Atherosclerosis is a hardening of the arteries due to the build-up of plaques made up of fatty materials such as cholesterol. These plaques may eventually rupture, leading to clots and subsequent arterial narrowing or blockage, which results in insufficient blood supply to tissues and organs.

Although immune cells have been shown to play important roles in the genesis of artherosclerotic plaques, the contribution of neutrophils, the most abundant white blood cell in circulation, remains unclear. Therefore, Rotzius et al examined the role of neutrophils in a mouse model of atherosclerosis. They found that neutrophils accumulate in atherosclerotic lesions, although at lower levels than other white blood cells. Moreover, neutrophils are the predominant immune cells in the high inflammatory shoulder regions of plaques, suggesting that these cells may play a hitherto unappreciated role in the immunological processes of atherogenesis.

Dr. Eriksson's group concludes that "[their] data provide strong evidence for the presence and invasion of significant numbers of neutrophils in atherosclerotic lesions. These findings call for further investigation of the functional importance of neutrophils and their interplay with complex immunological processes in atherogenesis."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rotzius et al. Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE-/- Mice. American Journal Of Pathology, 2010; DOI: 10.2353/ajpath.2010.090480

Cite This Page:

American Journal of Pathology. "Immune Cells and Atherosclerosis." ScienceDaily. ScienceDaily, 25 June 2010. <www.sciencedaily.com/releases/2010/06/100625124501.htm>.
American Journal of Pathology. (2010, June 25). Immune Cells and Atherosclerosis. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/06/100625124501.htm
American Journal of Pathology. "Immune Cells and Atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2010/06/100625124501.htm (accessed October 1, 2014).

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