Featured Research

from universities, journals, and other organizations

Alzheimer's disease: Some cells more prone to death

Date:
August 8, 2010
Source:
American Journal of Pathology
Summary:
Scientists have discovered that hyperploid neurons, which have greater than the normal number of chromosomes, are more prone to cell death in Alzheimer's disease.

A group led by Dr. Andreas Lφsche of the University of Leipzip, Germany has discovered that hyperploid neurons, which have greater than the normal number of chromosomes, are more prone to cell death in Alzheimer's disease. They present these findings in the July 2010 issue of The American Journal of Pathology.

Alzheimer's disease, the most common form of dementia, affects nearly 19% of people 75-84 years of age. Alzheimer's disease in incurable and degenerative, and results in death for the patient and considerable burden on the caregiver. Disease progression is associated with neuronal cell death.

Although a low-level of aneuploidy, an abnormal number of chromosomes, may contribute to neuronal diversity, high levels of aneuploidy may result in developmental abnormalities and disease. Ardendt et al explored the effects of hyperploidy, having greater than the normal number of chromosomes, in Alzheimer's disease pathogenesis. They identified increased numbers of hyperploid cells in preclinical stages of Alzheimer's disease and showed that hyperploid neuronal cells in Alzheimer's disease have selectively higher levels of cell death than normal neuronal cells. These results highlight hyperploidy, perhaps as a result of a failure of neuronal differentiation, as critical pathogenic event in neurodegeneration.

Dr. Lφsche's group suggests that "hyperploidy … [is one] critical molecular event … shared between neurodegeneration and malignant cell transformation … [and that these data] direct our attention to a failure of neuronal differentiation as the critical pathogenetic event and potential therapeutic target in neurodegeneration."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Arendt et al. Selective Cell Death of Hyperploid Neurons in Alzheimer's Disease. American Journal Of Pathology, 2010; DOI: 10.2353/ajpath.2010.090955

Cite This Page:

American Journal of Pathology. "Alzheimer's disease: Some cells more prone to death." ScienceDaily. ScienceDaily, 8 August 2010. <www.sciencedaily.com/releases/2010/06/100625124544.htm>.
American Journal of Pathology. (2010, August 8). Alzheimer's disease: Some cells more prone to death. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/06/100625124544.htm
American Journal of Pathology. "Alzheimer's disease: Some cells more prone to death." ScienceDaily. www.sciencedaily.com/releases/2010/06/100625124544.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins