Featured Research

from universities, journals, and other organizations

Alzheimer's disease: Some cells more prone to death

Date:
August 8, 2010
Source:
American Journal of Pathology
Summary:
Scientists have discovered that hyperploid neurons, which have greater than the normal number of chromosomes, are more prone to cell death in Alzheimer's disease.

A group led by Dr. Andreas Lφsche of the University of Leipzip, Germany has discovered that hyperploid neurons, which have greater than the normal number of chromosomes, are more prone to cell death in Alzheimer's disease. They present these findings in the July 2010 issue of The American Journal of Pathology.

Alzheimer's disease, the most common form of dementia, affects nearly 19% of people 75-84 years of age. Alzheimer's disease in incurable and degenerative, and results in death for the patient and considerable burden on the caregiver. Disease progression is associated with neuronal cell death.

Although a low-level of aneuploidy, an abnormal number of chromosomes, may contribute to neuronal diversity, high levels of aneuploidy may result in developmental abnormalities and disease. Ardendt et al explored the effects of hyperploidy, having greater than the normal number of chromosomes, in Alzheimer's disease pathogenesis. They identified increased numbers of hyperploid cells in preclinical stages of Alzheimer's disease and showed that hyperploid neuronal cells in Alzheimer's disease have selectively higher levels of cell death than normal neuronal cells. These results highlight hyperploidy, perhaps as a result of a failure of neuronal differentiation, as critical pathogenic event in neurodegeneration.

Dr. Lφsche's group suggests that "hyperploidy … [is one] critical molecular event … shared between neurodegeneration and malignant cell transformation … [and that these data] direct our attention to a failure of neuronal differentiation as the critical pathogenetic event and potential therapeutic target in neurodegeneration."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Arendt et al. Selective Cell Death of Hyperploid Neurons in Alzheimer's Disease. American Journal Of Pathology, 2010; DOI: 10.2353/ajpath.2010.090955

Cite This Page:

American Journal of Pathology. "Alzheimer's disease: Some cells more prone to death." ScienceDaily. ScienceDaily, 8 August 2010. <www.sciencedaily.com/releases/2010/06/100625124544.htm>.
American Journal of Pathology. (2010, August 8). Alzheimer's disease: Some cells more prone to death. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2010/06/100625124544.htm
American Journal of Pathology. "Alzheimer's disease: Some cells more prone to death." ScienceDaily. www.sciencedaily.com/releases/2010/06/100625124544.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) — The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) — A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) — A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) — A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins