Featured Research

from universities, journals, and other organizations

Novel Mechanism of Immune Cell Adhesion

Date:
June 25, 2010
Source:
American Journal of Pathology
Summary:
Researchers implicate sphingosine kinase-1 in neutrophil recruitment to sites of inflammation.

Researchers led by Dr. Claudine S. Bonder of the University of Adelaide, Adelaide, South Australia, Australia implicate sphingosine kinase-1 in neutrophil recruitment to sites of inflammation. They report their data in the July 2010 issue of The American Journal of Pathology.

Neutrophils, which make up nearly 70% of white blood cell in the blood stream, are first-responder immune cells that migrate to sites of infection and inflammation, where they secrete inflammatory molecules and fight pathogens. These and other white blood cells are targeted to sites of inflammation and infection via adhesive molecules, such as integrins, that are upregulated on the surface of blood vessels.

To determine if sphingosine kinase-1, an enzyme that both cleaves and generates important signaling molecules within cells, contributes to integrin-mediated neutrophil recruitment, Sun et al examined inflammatory responses in a model of human blood vessels. Sphingosine kinase-1 was required for integrin activation and subsequent neutrophin adhesion in this system. Taken together, these data support sphingosine kinase-1 as a broad-spectrum target for inhibiting neutrophil recruitment and subsequent inflammatory and immune disorders.

Dr. Bonder and colleagues "suggest that [sphingosine kinase-1 may be the single target required for an effective broad spectrum therapeutic target to combat inflammatory and immune disorders."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sun WY, Pitson SM, Bonder CS. Tumor necrosis factor-induced neutorphil adhesion occurs via sphingosine kinase-1-dependent actuaion of endothelial integrin. Am J Pathol, 2010, 177: 436-446

Cite This Page:

American Journal of Pathology. "Novel Mechanism of Immune Cell Adhesion." ScienceDaily. ScienceDaily, 25 June 2010. <www.sciencedaily.com/releases/2010/06/100625124630.htm>.
American Journal of Pathology. (2010, June 25). Novel Mechanism of Immune Cell Adhesion. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2010/06/100625124630.htm
American Journal of Pathology. "Novel Mechanism of Immune Cell Adhesion." ScienceDaily. www.sciencedaily.com/releases/2010/06/100625124630.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins