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Novel Mechanism of Immune Cell Adhesion

Date:
June 25, 2010
Source:
American Journal of Pathology
Summary:
Researchers implicate sphingosine kinase-1 in neutrophil recruitment to sites of inflammation.
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FULL STORY

Researchers led by Dr. Claudine S. Bonder of the University of Adelaide, Adelaide, South Australia, Australia implicate sphingosine kinase-1 in neutrophil recruitment to sites of inflammation. They report their data in the July 2010 issue of The American Journal of Pathology.

Neutrophils, which make up nearly 70% of white blood cell in the blood stream, are first-responder immune cells that migrate to sites of infection and inflammation, where they secrete inflammatory molecules and fight pathogens. These and other white blood cells are targeted to sites of inflammation and infection via adhesive molecules, such as integrins, that are upregulated on the surface of blood vessels.

To determine if sphingosine kinase-1, an enzyme that both cleaves and generates important signaling molecules within cells, contributes to integrin-mediated neutrophil recruitment, Sun et al examined inflammatory responses in a model of human blood vessels. Sphingosine kinase-1 was required for integrin activation and subsequent neutrophin adhesion in this system. Taken together, these data support sphingosine kinase-1 as a broad-spectrum target for inhibiting neutrophil recruitment and subsequent inflammatory and immune disorders.

Dr. Bonder and colleagues "suggest that [sphingosine kinase-1 may be the single target required for an effective broad spectrum therapeutic target to combat inflammatory and immune disorders."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sun WY, Pitson SM, Bonder CS. Tumor necrosis factor-induced neutorphil adhesion occurs via sphingosine kinase-1-dependent actuaion of endothelial integrin. Am J Pathol, 2010, 177: 436-446

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American Journal of Pathology. "Novel Mechanism of Immune Cell Adhesion." ScienceDaily. ScienceDaily, 25 June 2010. <www.sciencedaily.com/releases/2010/06/100625124630.htm>.
American Journal of Pathology. (2010, June 25). Novel Mechanism of Immune Cell Adhesion. ScienceDaily. Retrieved May 25, 2015 from www.sciencedaily.com/releases/2010/06/100625124630.htm
American Journal of Pathology. "Novel Mechanism of Immune Cell Adhesion." ScienceDaily. www.sciencedaily.com/releases/2010/06/100625124630.htm (accessed May 25, 2015).

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