Featured Research

from universities, journals, and other organizations

New research model of human prostate cancer shows cancer development

Date:
July 6, 2010
Source:
The Endocrine Society
Summary:
Progress toward understanding the role of sex hormones in the growth of prostate cancer -- the most common cancer in US men -- has been hindered by the lack of a suitable laboratory research model. Now researchers say they have developed the first model of hormone-induced human prostate cancer initiation and progression.

Progress toward understanding the role of sex hormones in the growth of prostate cancer -- the most common cancer in U.S. men -- has been hindered by the lack of a suitable laboratory research model. Now researchers say they have developed the first model of hormone-induced human prostate cancer initiation and progression.

Related Articles


Their results were presented at The Endocrine Society's 92nd Annual Meeting in San Diego.

"We hope this model will speed up the process of testing preventive therapies for prostate cancer as well as help clarify the hormonal mechanisms in the development of this cancer," said Gail Prins, PhD, a professor and reproductive physiologist at the University of Illinois at Chicago, who is a co-author of the study.

"Sex hormones -- testosterone and estrogens -- are involved in regulating the growth of prostate cancer, but the mechanisms are not well established," Prins said.

Currently the only available laboratory models of human prostate cancer are xenografts -- cancerous human tissues grafted under the skin of animals -- or "transformed" cancer cell lines containing cells that originally came from patients with prostate cancer. However, Prins said, "If you want to study the initial development of cancer -- either naturally or induced -- or its prevention, you cannot use a model of existing cancer, such as transformed cell lines."

To study the progression of prostate cancer from normal cells into cancerous cells requires the use of animal prostate cells. Animal models, however, do not directly mimic all aspects of human prostate cancer, experts say.

Prins and her colleagues created their model using prostate cells obtained from a deceased organ donor who did not have prostate disease. They isolated and grew, in 3-D culture, adult prostate progenitor cells -- cells with stem cell-like properties that self-renew and may become cancerous. In 3-D culture, the progenitor cells proliferate and form small spheroids, called prostaspheres, which are capable of regenerating tissues.

The researchers combined these human prostaspheres with embryonic cells from the prostate of a rat and then transplanted the mixed cells under the kidney capsule of mice. These transplants regenerated into normal human prostate-like tissues and secreted prostate-specific antigen (PSA), which confirmed human functionality, according to Prins.

The mice then received a drug pellet containing testosterone and estradiol estrogen. A cancerous tumor formed at the transplant site.

"We were able to induce hormonally driven prostate cancer in these recombinant tissues," Prins said. "Using this model, we can follow the entire pathway of the cancer -- from normal tissue to initiation and progression."


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

The Endocrine Society. "New research model of human prostate cancer shows cancer development." ScienceDaily. ScienceDaily, 6 July 2010. <www.sciencedaily.com/releases/2010/07/100701072700.htm>.
The Endocrine Society. (2010, July 6). New research model of human prostate cancer shows cancer development. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2010/07/100701072700.htm
The Endocrine Society. "New research model of human prostate cancer shows cancer development." ScienceDaily. www.sciencedaily.com/releases/2010/07/100701072700.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins